J
Jo Spencer
Researcher at King's College London
Publications - 171
Citations - 12045
Jo Spencer is an academic researcher from King's College London. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 48, co-authored 156 publications receiving 11345 citations. Previous affiliations of Jo Spencer include University College London & Guy's and St Thomas' NHS Foundation Trust.
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Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine).
TL;DR: In enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine) in which the 'uninvolved mucosa' is histologically similar to untreated coeliac disease, the changes in the intraepithelial T cell sub-sets are indistinguishable from those in coelcream disease, suggesting that the lymphoma is a complication of coeliasis.
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Human marginal-zone B cells
TL;DR: Marginal-zone B cells are likely to be the first B cells in lymphoid tissue to encounter antigen, but this does not reflect a specific function, since the population appears to be functionally heterogeneous.
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Human Peyer's patches: an immunohistochemical study.
TL;DR: The mantle zones of the B cell follicles in human Peyer's patches were surrounded by B cells which did not express surface IgD but which mostly expressed surface immunoglobulin of the IgM and/or IgA1 isotype, and cells expressing surface IgG or IgA2 were detected.
Journal Article
Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type
TL;DR: This study suggests that autoimmunity may play a role in the pathogenesis of gastric lymphoma.
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Mouse and human intestinal immunity: same ballpark, different players; different rules, same score
TL;DR: This review will consider general differences in the structure and development of human and mouse mucosal lymphoid microenvironments and then discuss species differences in mucosal B- and T-cell biology that relate to the current concepts of intestinal immune function.