J
Johannes P. C. van den Akker
Researcher at Erasmus University Rotterdam
Publications - 25
Citations - 2433
Johannes P. C. van den Akker is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 10, co-authored 20 publications receiving 1557 citations. Previous affiliations of Johannes P. C. van den Akker include Erasmus University Medical Center.
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Journal ArticleDOI
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.
Daniela Weiskopf,Katharina S. Schmitz,Matthijs P. Raadsen,Alba Grifoni,Nisreen M.A. Okba,Henrik Endeman,Johannes P. C. van den Akker,Richard Molenkamp,Marion Koopmans,Eric C. M. van Gorp,Bart L. Haagmans,Rik L. de Swart,Alessandro Sette,Alessandro Sette,Rory D. de Vries +14 more
TL;DR: Study of COVID-19 patients who required admission to an intensive care unit and detected SARS-CoV-2-specific CD4+ and CD8+ T cells detected shed light on the potential variations in T-cell responses as a function of disease severity, an issue that is key to understanding the potential role of immunopathology in the disease.
Journal ArticleDOI
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19).
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: In this paper, the authors report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19, and that the median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5-11) and drops below 5% after 15.2 days after onset of symptom (95% confidence interval (CI) 13.4-17.2).
Journal ArticleDOI
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment.
Corine H. GeurtsvanKessel,Nisreen M.A. Okba,Zsofia Igloi,Susanne Bogers,Carmen W.E. Embregts,Brigitta M. Laksono,Lonneke M. Leijten,Casper Rokx,Bart J. A. Rijnders,Janette Rahamat-Langendoen,Johannes P. C. van den Akker,Jeroen J. A. van Kampen,Annemiek A. van der Eijk,Rob van Binnendijk,Bart L. Haagmans,Marion Koopmans +15 more
TL;DR: The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies.
Posted ContentDOI
Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: Infectious virus shedding drops to undetectable levels below a viral RNA load threshold and once serum neutralizing antibodies are present, which warrants the use of quantitative viralRNA load assays and serological assays in test-based strategies to discontinue or de-escalate infection prevention and control precautions.
Journal ArticleDOI
Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis
TL;DR: Invasive MV is associated with a threefold increase in the odds of developing AKI and various Vt or PEEP settings do not modify this risk, which argues in favour of a haemodynamic origin of AKI during MV.