John F. Forbes

TL;DR: Evaluation of the types of first relapse avoided by available treatments may explain why effects on mortality are small and appear late during follow-up, and more intensive treatments at present being tested in clinical trials might affect bone and visceral relapses and have a greater and earlier influence on survival.

TL;DR: Extended intermittent use of adjuvant letrozole in postmenopausal women with hormone receptor-positive, lymph node- positive, and operable breast cancer for which they had undergone local treatment and had completed 4-6 years of adjUvant endocrine therapy is hypothesised to improve breast cancer outcome compared with continuous use of letroZole.

TL;DR: The data demonstrate that overexpression of EMS1 mRNA is largely due to EMS1 gene amplification, is independent of cyclin D1 and ER expression and, in contrast to cycl in D1, is not regulated by oestrogen.

TL;DR: Bhopal et al. as discussed by the authors studied the effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of Type 2 diabetes in a family-cluster randomised controlled trial.

TL;DR: Novel insight is provided into the repertoire of miRNAs that contribute to the initiation of and progression to lymph node metastasis in triple negative breast cancer and have important implications for the treatment of this breast cancer subtype.