J
John Fisher
Researcher at Regeneron
Publications - 2
Citations - 708
John Fisher is an academic researcher from Regeneron. The author has contributed to research in topics: Receptor tyrosine kinase & GAS6. The author has an hindex of 1, co-authored 1 publications receiving 671 citations.
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Journal ArticleDOI
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
TL;DR: The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.
Journal ArticleDOI
Lead Optimization of Cathepsin K Inhibitors for the Treatment of Osteoarthritis.
Anthony Ginnetti,Daniel V. Paone,Kausik K. Nanda,Jing Li,Marina Busuek,Scott A. Johnson,Jun Lu,Stephen M. Soisson,Ronald G. Robinson,John Fisher,Andrea M. Webber,Gregg Wesolowski,Bennett Ma,Le T. Duong,Steven L. Carroll,Christopher S. Burgey,Shawn J. Stachel +16 more
TL;DR: The SAR studies which led to the discovery of the highly selective oxazole compound 23, which was subsequently shown to inhibit cathepsin K in vivo as measured by reduced levels of urinary C-telopeptide of collagen type I in dog.