The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
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TLDR
The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.About:
This article is published in Cell.The article was published on 1995-02-24 and is currently open access. It has received 705 citations till now. The article focuses on the topics: Receptor tyrosine kinase & AXL receptor tyrosine kinase.read more
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Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Samuel Davis,Aldrich Thomas H,Pamela F. Jones,Ann Acheson,Debra L Compton,Vivek Jain,Terence E Ryan,Joanne Bruno,Czeslaw Radziejewski,Maisonpierre Peter C,George D. Yancopoulos +10 more
TL;DR: The identification of a secreted ligand for TIE2, termed Angiopoietin-1, is reported using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells.
Journal ArticleDOI
Increased bone formation in osteocalcin-deficient mice
Patricia Ducy,Christelle Desbois,Brendan F. Boyce,Gerald J. Pinero,Beryl Story,Colin R. Dunstan,Erica Smith,Jeffrey Bonadio,Steven A. Goldstein,Caren M. Gundberg,Allan Bradley,Gerard Karsenty +11 more
TL;DR: This study provides the first evidence that osteocalcin is a determinant of bone formation, and generates osteocalin-deficient mice that develop a phenotype marked by higher bone mass and bones of improved functional quality.
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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Anna V. Molofsky,Ricardo Pardal,Toshihide Iwashita,In-Kyung Park,Michael F. Clarke,Sean J. Morrison,Sean J. Morrison +6 more
TL;DR: It is shown that Bmi-1 is required for the self-renewal of stem cells in the peripheral and central nervous systems but not for their survival or differentiation but restricted neural progenitors from the gut and forebrain proliferate normally in the absence of B mi-1.
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TAM receptors are pleiotropic inhibitors of the innate immune response.
TL;DR: A self-regulating cycle of inflammation is illuminated, in which the obligatory, cytokine-dependent activation of TAM signaling hijacks a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokines-driven immune responses.
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Immunobiology of the TAM receptors
Greg Lemke,Carla V. Rothlin +1 more
TL;DR: Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.
References
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Michael S. O'Reilly,Michael S. O'Reilly,Lars Holmgren,Lars Holmgren,Yuen Shing,Yuen Shing,Catherine Chen,Catherine Chen,Rosalind A. Rosenthal,Rosalind A. Rosenthal,Marsha A. Moses,Marsha A. Moses,William S. Lane,Yihai Cao,E. Helene Sage,Judah Folkman +15 more
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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
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TL;DR: This laboratory manual simplifies selection of the most appropriate baculovirus vector design for a given problem by describing each step of the implementation process - from vector construction to large-scale protein production.
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Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Donald P. Bottaro,Jeffrey S. Rubin,D. L. Faletto,Andrew K Chan,Thomas E. Kmiecik,G F Vande Woude,Stuart A. Aaronson +6 more
TL;DR: A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase.
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Growth factor signaling by receptor tyrosine kinases
Joseph Schlessinger,Axel Ullrich +1 more