Badarch Uranchimeg

TL;DR: It is described that oxygen availability is a determinant parameter in the setting of chemotactic responsiveness to stromal-derived factor 1 (CXCL12), and the Hyp–Hyp-inducible factor 1 α–CXCR4 pathway may regulate trafficking in and out of hypoxic tissue microenvironments.

TL;DR: The luciferase-based high-throughput screen is a feasible tool for the identification of small molecule inhibitors of HIF-1 transcriptional activation and the results suggest that altered Topo-I function may be associated with repression of Hif-1-dependent induction of gene expression.

TL;DR: It is demonstrated that TPT does not affect Hif-1α protein half-life or mRNA accumulation but inhibits its translation, and the existence of a novel pathway connecting Top 1-dependent signaling events and the regulation of HIF-1 α protein expression and function is demonstrated.

TL;DR: The results uncover the existence of an HIF-1alpha-bFGF amplification pathway that mediates survival and sprouting of endothelial cells under hypoxic conditions.

TL;DR: Daily administration of topotecan inhibits HIF-1α protein expression in U251-HRE glioblastoma xenografts and causes a significant tumor growth inhibition associated with a marked decrease of angiogenesis and expression of Hif-1 target genes in tumor tissue.