John Isaac

TL;DR: Viability assessment of high‐risk grafts using NMP‐L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction, which may increase organ availability for LT.

TL;DR: 5-year graft survival in donation after cardiac death livers treated by conventional cold storage, or by 1-2 h of hypothermic oxygenated perfusion (HOPE) after cold storage suggests that a simple end-ischaemic perfusion approach is very effective and may open the field for safe utilisation of extended DCD liver grafts.

TL;DR: The VITTAL clinical trial as discussed by the authors used normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria, which enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent nonanastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.

TL;DR: The UK DCD Risk Score is a reliable tool to detect high-risk and futile combinations of donor-and-recipient factors in DCD liver transplantation and offers a great potential for making better decisions on which DCD graft should be rejected or may benefit from functional assessment and further optimization by machine perfusion.

TL;DR: The early diagnosis of hepatic artery thrombosis (HAT) decreases septic complications, multiorgan failure, and graft loss, and there are better outcomes after treatment as discussed by the authors.