Showing papers in "Liver Transplantation in 2014"

TL;DR: The incidence of postoperative sepsis was reduced even in patients with sarc Openia after the routine application of early enteral nutrition, and sarcopenia is an independent predictor of mortality andSepsis after LDLT.

TL;DR: An AFP level may be a surrogate for vascular invasion and may be used to predict posttransplant HCC recurrence and Incorporating an AFP level > 1000 ng/mL as an exclusion criterion for LT within the Milan criteria may further improve posttrans transplant outcomes.

TL;DR: Preoperative quality and quantity of skeletal muscle could be incorporated into new selection criteria for LDLT, and perioperative nutritional therapy and rehabilitation could be important for good outcomes after LDLT.

TL;DR: In this paper, the skeletal muscle cross-sectional area was measured with CT, and sarcopenia was defined with previously published sex- and body mass index-specific cutoffs.

TL;DR: The early diagnosis of hepatic artery thrombosis (HAT) decreases septic complications, multiorgan failure, and graft loss, and there are better outcomes after treatment as discussed by the authors.

TL;DR: The first multicenter prognostic model for the prediction of early post‐LT CVD death, the most common cause of earlyPost‐LT mortality in the current transplant era, is provided.

TL;DR: cHCC‐CC patients appear to have intermediate demographic, clinical, and survival characteristics in comparison with HCC and CC patients, and MJH may be considered the best therapeutic approach for such patients.

TL;DR: In this paper, the effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) livers after transplantation have not been addressed thoroughly and represent the objective of this study.

TL;DR: Recurrent NAFLD appears to be a more severe and irreversible disease with an earlier onset; de novoNAFLD after LT are different entities.

TL;DR: Liver allograft recipients with preformed DSAs with a high mean fluorescence intensity despite dilution seem to be at risk for clinically significant allografted injury and possibly for loss from AMR, often in combination with ACR.

TL;DR: Early post‐LT morbidity is highest for patients with concomitant obesity and DM, although these factors do not appear to influence recipient survival, and BMI is an adequate tool for assessing obesity‐associated risk in LT.

TL;DR: LDT is still an excellent alternative to DDLT because it facilitates access to LT and a reduction of postoperative complication rates can be achieved as centers gain greater experience with LDLT.

TL;DR: The MLVI is associated with and can predict rejection, possibly related to nonadherence, in adult liver transplant recipients.

TL;DR: Delaying LT for HCC may reduce disparities in ITT survival and access to LT among different indications and thereby improve system utility and organ allocation equity for the overall pool of LT candidates.

TL;DR: EAD results in inferior patient and graft survival in recipients of DCD liver allografts, and the events that cause EAD and developing preventive or early therapeutic approaches should be the focus of future investigations.

TL;DR: A quantitative comparison of FK18 (necrosis) and CK18 (apoptosis) release indicated dominant cell death by necrosis during IRP and only a temporary and very minor degree of apoptosis, which suggests that the focus of future research should be the elucidation of necrotic signaling mechanisms to identify relevant targets, which may be used to attenuate hepatic IRP injury.

TL;DR: In patients who did not undergo transplantation, impaired AT was predictive of mortality, and in patients undergoing LT, it was related to postoperative hospitalization and survival, and AC should be evaluated as a modifiable factor for improving patient survival whether or not LT is anticipated.

TL;DR: The risk of HCC recurrence within the first year after transplantation may be lessened by the institution of a mandatory waiting time after an exception is granted, as compared with rapid transplant patients and their slower transplant counterparts.

TL;DR: Rather than selecting patients on the basis of preoperative alcohol use, sociomedical support should be provided to improve adherence after LT for ALC in Japan to prevent recidivism.

TL;DR: Increases in the frequencies of CATH and PCI corresponded to significant reductions in postoperative MIs and 1‐year all‐cause mortality rates, and a significant improvement in the overall survival rate over the 3 analyzed time periods was noted.

TL;DR: Grade 3‐4 HE at time of wait‐list registration significantly increases 90‐day wait‐ list mortality independent of MELD score, and incorporating HE in the assessment of LT priority may improve prognostication of liver disease severity and prioritization for LT.

TL;DR: In this paper, the authors created training and validation cohorts of putative acute AMR and control cases from three high-volume liver transplant programs; these cases were evaluated blindly by 4 independent transplant pathologists.

TL;DR: In this article, the authors evaluated whether platelet counts could be indicators of short and long-term outcomes after liver transplantation and found that patients with low platelet count were a risk factor for postoperative complications and graft and patient survival.

TL;DR: Sequential SNevLP preservation of DCD grafts reduces bile duct and EC injury after liver transplantation and no difference was observed between SNEVLP‐ and CS‐treated animals with respect to the peak of serum INR, factor V, or AST levels within 24 hours.

TL;DR: The impact of early biliary complications was greater for DCD liver recipients, but they remained highly significant for recipients of allografts from brain‐dead donors as well.

TL;DR: Patients with a history of OHE showed greater improvements after LT than patients with a negative history, but their global cognitive function remained slightly worse; in contrast, EEGs normalized in both groups.

TL;DR: Despite the increasing proportion of patients with HCC diagnosed at an earlier stage, LT rates declined in the most recent era, and ethnic minorities were significantly less likely to undergo LT.

TL;DR: It is suggested that the surgical management of anastomotic BCs may constitute the first and best therapeutic option in pediatric LT and surgery as a first treatment option for anastoms could allow a definitive cure for the majority of these patients.

TL;DR: Patients with POPH responsive to vasodilator therapy may have excellent long‐term graft and patient survival after OLT, despite the alleviation of portal hypertension by OLT.