Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Hynek Mergental,Hynek Mergental,M. T. P. R. Perera,Richard W. Laing,Paolo Muiesan,John Isaac,Amanda Smith,Barney Stephenson,Hentie Cilliers,Desley Neil,Stefan G. Hubscher,Simon C. Afford,Darius F. Mirza +12 more
TLDR
Viability assessment of high‐risk grafts using NMP‐L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction, which may increase organ availability for LT.About:
This article is published in American Journal of Transplantation.The article was published on 2016-11-01 and is currently open access. It has received 257 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more
TL;DR: Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.
Journal ArticleDOI
Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches
Gonzalo Sapisochin,Jordi Bruix +1 more
TL;DR: A comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment is provided.
Journal ArticleDOI
Observations on the ex situ perfusion of livers for transplantation.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Caitlin Pley,Lucy V. Randle,Corinna Fear,Keziah Crick,Alexander Gimson,Michael Allison,Sara Upponi,Rebecca Brais,Ina Jochmans,Andrew J. Butler +11 more
TL;DR: Evaluation of bile pH may offer a valuable insight into bile duct integrity and risk of posttransplant ischemic cholangiopathy, as well as a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid‐base balance.
Journal ArticleDOI
Transplantation of discarded livers following viability testing with normothermic machine perfusion
Hynek Mergental,Hynek Mergental,Richard W. Laing,Richard W. Laing,Amanda Kirkham,M. Thamara P. R. Perera,Yuri L. Boteon,Yuri L. Boteon,Joseph Attard,Joseph Attard,Darren Barton,Stuart M. Curbishley,Stuart M. Curbishley,Manpreet Wilkhu,Desley Neil,Desley Neil,Stefan G. Hübscher,Stefan G. Hübscher,Paolo Muiesan,John Isaac,Keith J. Roberts,Keith J. Roberts,Manuel Abradelo,A. Schlegel,A. Schlegel,James Ferguson,Hentie Cilliers,Julian Bion,David H. Adams,David H. Adams,Christopher Morris,P Friend,Christina Yap,Christina Yap,Simon C. Afford,Simon C. Afford,Darius F. Mirza,Darius F. Mirza +37 more
TL;DR: The VITTAL clinical trial as discussed by the authors used normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria, which enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent nonanastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.
Journal ArticleDOI
Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death
van Rianne Rijn,Negin Karimian,Alix P M Matton,Laura C. Burlage,Andrie C. Westerkamp,A. P. van den Berg,de Ruben Kleine,de Marieke Boer,Ton Lisman,Robert J. Porte +9 more
TL;DR: The aim of this prospective case–control study was to assess the safety and feasibility of DHOPE in DCD liver transplantation.
References
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TL;DR: This 5-year evaluation provides strong evidence that the classification of complications is valid and applicable worldwide in many fields of surgery, and subjective, inaccurate, or confusing terms such as “minor or major” should be removed from the surgical literature.
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Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
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TL;DR: Hypothermic machine perfusion was associated with a reduced risk of delayed graft function and improved graft survival in the first year after transplantation.
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Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
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UK health performance: findings of the Global Burden of Disease Study 2010
Christopher J L Murray,Michael Richards,John N Newton,Kevin A. Fenton,H. Ross Anderson,Charles Atkinson,Derrick A Bennett,Eduardo Bernabé,Hannah Blencowe,Rupert R A Bourne,Tasanee Braithwaite,Carol Brayne,Nigel Bruce,Traolach S. Brugha,Peter Burney,Mukesh Dherani,Helen Dolk,Karen Edmond,Majid Ezzati,Abraham D. Flaxman,Thomas D. Fleming,Greg Freedman,David Gunnell,Roderick J. Hay,Sally Hutchings,Summer Lockett Ohno,Rafael Lozano,Ronan A Lyons,Wagner Marcenes,Mohsen Naghavi,Charles R. Newton,Neil Pearce,Daniel Pope,Lesley Rushton,Joshua A. Salomon,Kenji Shibuya,Theo Vos,Haidong Wang,Hywel C Williams,Anthony D. Woolf,Alan D. Lopez,Adrian Davis +41 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) as mentioned in this paper examined the patterns of health loss in the UK, the leading preventable risks that explain some of these patterns, and how UK outcomes compare with a set of comparable countries in the European Union and elsewhere in 1990 and 2010.
Journal ArticleDOI
Addressing liver disease in the UK: A blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis
Roger Williams,Richard Aspinall,Mark A Bellis,Ginette Camps-Walsh,Matthew E. Cramp,Anil Dhawan,James Ferguson,Daniel M. Forton,Graham R. Foster,Sir Ian Gilmore,Matthew Hickman,Mark Hudson,Deirdre Kelly,Andrew Langford,Martin Lombard,Louise Longworth,Natasha K. Martin,Kieran Moriarty,Philip N. Newsome,John O'Grady,Rachel Pryke,Harry Rutter,Stephen D. Ryder,Nick Sheron,Thomas J. Smith +24 more
TL;DR: The aim of this Commission is to provide the strongest evidence base through involvement of experts from a wide cross-section of disciplines, making firm recommendations to reduce the unacceptable premature mortality and disease burden from avoidable causes and to improve the standard of care for patients with liver disease in hospital.
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A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more