J
John Nielsen
Researcher at University of Copenhagen
Publications - 147
Citations - 7431
John Nielsen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Quorum sensing & Solid-phase synthesis. The author has an hindex of 39, co-authored 145 publications receiving 6849 citations. Previous affiliations of John Nielsen include University of Colorado Boulder & Technical University of Denmark.
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Patent
Encoded combinatorial chemical libraries
TL;DR: In this article, an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer is described.
Journal ArticleDOI
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector
Thomas Bovbjerg Rasmussen,Thomas Bjarnsholt,Mette E. Skindersoe,Morten Hentzer,Peter Kristoffersen,Manuela Köte,John Nielsen,Leo Eberl,Leo Eberl,Michael Givskov +9 more
TL;DR: GeneChip-based transcriptome analysis revealed that garlic extract and 4-NPO had specificity for QS-controlled virulence genes in Pseudomonas aeruginosa, and these two QSIs significantly reduced P. aerug inosa biofilm tolerance to tobramycin treatment as well as virulence in a Caenorhabditis elegans pathogenesis model.
Journal ArticleDOI
Advanced glycation endproducts in food and their effects on health.
Malene W. Poulsen,Rikke Susanne Vingborg Hedegaard,Jeanette M. Andersen,Barbora de Courten,Barbora de Courten,Susanne Bügel,John Nielsen,Leif H. Skibsted,Lars O. Dragsted +8 more
TL;DR: The current review points out several research needs in order to address important questions on AGEs in foods and health.