J
John T. McCrone
Researcher at University of Edinburgh
Publications - 47
Citations - 8799
John T. McCrone is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Influenza A virus & Pandemic. The author has an hindex of 24, co-authored 44 publications receiving 4346 citations. Previous affiliations of John T. McCrone include University of Missouri & University of Michigan.
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Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking epidemiological and genetic data
Erik M. Volz,Swapnil Mishra,Meera Chand,Jeffrey C. Barrett,Robert Johnson,Lily Geidelberg,Wes Hinsley,Daniel J Laydon,Gavin Dabrera,Áine O'Toole,Roberto Amato,Manon Ragonnet-Cronin,Ian Harrison,Ben Jackson,Cristina V. Ariani,Olivia Boyd,Nicholas J. Loman,John T. McCrone,Sónia Gonçalves,David Jorgensen,Richard M. Myers,Verity Hill,David K. Jackson,Katy A. M. Gaythorpe,Natalie Groves,John Sillitoe,Dominic P. Kwiatkowski,Cog-Uk,Seth Flaxman,Oliver Ratman,Samir Bhatt,Susan Hopkins,Axel Gandy,Andrew Rambaut,Neil M. Ferguson +34 more
TL;DR: The SARS-CoV-2 lineage B.7, now designated Variant of Concern 202012/01 (VOC) by Public Health England, originated in the UK in late Summer to early Autumn 2020 as mentioned in this paper.
Posted ContentDOI
Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity
Erik M. Volz,Verity Hill,John T. McCrone,Anna Price,David Jorgensen,Áine O'Toole,Joel Southgate,Robert Johnson,Ben Jackson,Fabrícia F. Nascimento,Sara Rey,Samuel M. Nicholls,Rachel M. Colquhoun,Ana da Silva Filipe,James G Shepherd,David J Pascall,Rajiv Shah,Natasha Jesudason,Kathy Li,Ruth F. Jarrett,Nicole Pacchiarini,Matthew J. Bull,Lily Geidelberg,Igor Siveroni,Ian Goodfellow,Nicholas J. Loman,Oliver G. Pybus,Oliver G. Pybus,David Robertson,E. Thomson,Andrew Rambaut,Thomas R. Connor,Thomas R. Connor +32 more
TL;DR: Investigation of the hypothesis for positive selection of Spike 614G at the level of an individual country, the United Kingdom, using more than 25,000 whole genome SARS-CoV-2 sequences collected by COVID-19 Genomics UK Consortium finds that Spike 6 14G clusters are introduced in the UK later on average than 614D clusters and grow to larger size after adjusting for time of introduction.
Journal ArticleDOI
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.
Louis du Plessis,John T. McCrone,Alexander E. Zarebski,Verity Hill,Christopher Ruis,Bernardo Gutierrez,Bernardo Gutierrez,Jayna Raghwani,Jordan Ashworth,Rachel M. Colquhoun,Thomas R. Connor,Nuno R. Faria,Nuno R. Faria,Ben Jackson,Nicholas J. Loman,Áine O'Toole,Samuel M. Nicholls,Kris V Parag,Emily Scher,Tetyana I. Vasylyeva,Erik M. Volz,Alexander Watts,Isaac I. Bogoch,Kamran Khan,David M. Aanensen,Moritz U. G. Kraemer,Andrew Rambaut,Oliver G. Pybus,Oliver G. Pybus +28 more
TL;DR: The United Kingdom's COVID-19 epidemic during early 2020 was one of world's largest and was unusually well represented by virus genomic sampling as mentioned in this paper, which determined the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes, including 26,181 from the UK sampled throughout the country's first wave of infection.
Journal ArticleDOI
Genomic Epidemiology of SARS-CoV-2 in Guangdong Province, China.
Jing Lu,Louis du Plessis,Zhe Liu,Verity Hill,Min Kang,Huifang Lin,Jiufeng Sun,Sarah François,Moritz U. G. Kraemer,Nuno R. Faria,John T. McCrone,Jingju Peng,Qianlin Xiong,Runyu Yuan,Lilian Zeng,Pingping Zhou,Chumin Liang,Lina Yi,Jun Liu,Jianpeng Xiao,Jianxiong Hu,Tao Liu,Wenjun Ma,Wei Li,Juan Su,Huanying Zheng,Bo Peng,Shisong Fang,Wenzhe Su,Kuibiao Li,Ruilin Sun,Ru Bai,Xi Tang,Minfeng Liang,Josh Quick,Tie Song,Andrew Rambaut,Nicholas J. Loman,Jayna Raghwani,Oliver G. Pybus,Changwen Ke +40 more
TL;DR: Combined epidemiological and phylogenetic analyses indicate multiple independent introductions to Guangdong, although phylogenetic clustering is uncertain because of low virus genetic variation early in the pandemic.
Posted ContentDOI
A dynamic nomenclature proposal for SARS-CoV-2 to assist genomic epidemiology
Andrew Rambaut,Edward C. Holmes,Verity Hill,Áine O'Toole,John T. McCrone,Christopher Ruis,Louis du Plessis,Oliver G. Pybus +7 more
TL;DR: A rational and dynamic virus nomenclature that uses a phylogenetic framework to identify those lineages that contribute most to active spread of SARS-CoV-2 is presented in this paper.