다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Freedom of design, mass customisation, waste minimisation and the ability to manufacture complex structures, as well as fast prototyping, are the main benefits of additive manufacturing (AM) or 3D printing. A comprehensive review of the main 3D printing methods, materials and their development in trending applications was carried out. In particular, the revolutionary applications of AM in biomedical, aerospace, buildings and protective structures were discussed. The current state of materials development, including metal alloys, polymer composites, ceramics and concrete, was presented. In addition, this paper discussed the main processing challenges with void formation, anisotropic behaviour, the limitation of computer design and layer-by-layer appearance. Overall, this paper gives an overview of 3D printing, including a survey on its benefits and drawbacks as a benchmark for future research and development.

Additive manufacturing (3D printing): A review of materials, methods, applications and challenges

Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with the ability to be stretched, compressed, twisted, bent, and deformed into arbitrary shapes. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we review these strategies and describe applications of them in systems ranging from electronic eyeball cameras to deformable light-emitting displays. We conclude with some perspectives on routes to commercialization, new device opportunities, and remaining challenges for research.

http://science.sciencemag.org/content/sci/327/5973/1603.full.pdf

Materials and mechanics for stretchable electronics

Publisher Summary This chapter describes the mixed mode cracking in layered materials. There is ample experimental evidence that cracks in brittle, isotropic, homogeneous materials propagate such that pure mode I conditions are maintained at the crack tip. An unloaded crack subsequently subject to a combination of modes I and II will initiate growth by kinking in such a direction that the advancing tip is in mode I. The chapter also elaborates some of the basic results on the characterization of crack tip fields and on the specification of interface toughness. The competition between crack advance within the interface and kinking out of the interface depends on the relative toughness of the interface to that of the adjoining material. The interface stress intensity factors play precisely the same role as their counterparts in elastic fracture mechanics for homogeneous, isotropic solids. When an interface between a bimaterial system is actually a very thin layer of a third phase, the details of the cracking morphology in the thin interface layer can also play a role in determining the mixed mode toughness. The elasticity solutions for cracks in multilayers are also elaborated.

Mixed mode cracking in layered materials

For crack growth along an interface between dissimilar materials the effect of combined modes I, II and III at the crack-tip is investigated. First, in order to highlight situations where crack growth is affected by a mode III contribution, examples of material configurations are discussed where mode III has an effect. Subsequently, the focus is on crack growth along an interface between an elastic-plastic solid and an elastic substrate. The analyses are carried out for conditions of small-scale yielding, with the fracture process at the interface represented by a cohesive zone model. Due to the mismatch of elastic properties across the interface the corresponding elastic solution has an oscillating stress singularity, and this solution is applied as boundary conditions on the outer edge of the region analyzed. For several combinations of modes I, II and III crack growth resistance curves are calculated numerically in order to determine the steady-state fracture toughness. For given values of K I and K II the minimum fracture toughness corresponds to K III = 0 in most of the range analyzed, but there is a range where the minimum occurs for a nonzero value of K III .

http://web-static-aws.seas.harvard.edu/hutchinson/papers/ModeIIIVTJWH2008.pdf

Mode III effects on interface delamination

This paper addresses localization of the deformation due to buckling that occurs immediately following the onset of bifurcation in the axisymmetric buckling of a perfect spherical elastic shell subject to external pressure. The localization process is so abrupt that the buckling mode of the classical eigenvalue analysis, which undulates over the entire shell, becomes modified immediately after bifurcation transitioning to an isolated dimple surrounded by an unbuckled expanse of the shell. The paper begins by revisiting earlier attempts to analyze the initial post-buckling behavior of the spherical shell, illustrating their severely limited range of validity. The unsuccessful attempts are followed by an approximate Rayleigh-Ritz solution which captures the essence of the localization process. The approximate solution reveals the pathway that begins at bifurcation from the classical mode shape to the localized dimple buckle. The second part of the paper presents an exact asymptotic expansion of the initial post-buckling behavior which accounts for localization and which further exposes the analytic details of the abruptness of the transition.

Localization in spherical shell buckling

Optimal inextensional buckling of uniformly loaded simply supported arches with large opening angle

On optimal arches

This book is designed for use by students and teachers in the field of applied mechanics and mathematics, and for practitioners in civil and mechanical engineering Since tensor calculus is an indispensable prerequisite when dealing with the theory of elasticity in a modern way, the first part of the book consists in an introduction into this subject In the second part, the physical foundations of the theory of elasticity are given, including nonlinearities The excursion into the field of geometric and physical nonlinearities is done in order to prepare the reader for further advances into the most recent developments of the theory The book itself, in the remainder, is restricted to linear problems only The third part of the book deals with the mathematical theory of linear elasticity in full extent Curvilinear problems, two- and three-dimensional problems are included Stress has been put on working out a systematic approach to the solutions of all kinds of stress states, not neglecting triaxial problems Also, energy methods have been dealt with, taking into account the generalization and extension of these methods by Rudiger and Reiss ner The fourth and last part of the book consists in an application of the general methods, as outlined in part 3, to special structures like plates and shells, thus giving hopefully something of interest to the practising engineer"

Theory of Elasticity

We explore the effect of precisely defined geometric imperfections on the buckling load of spherical shells under external pressure loading, using finite element analysis that was previously validated through precision experiments. Our numerical simulations focus on the limit of large amplitude defects and reveal a lower bound that depends solely on the shell radius to thickness ratio and the angular width of the defect. It is shown that, in the large amplitude limit, the buckling load depends on an single geometric parameter, even for shells of moderate radius to thickness ratio. Moreover, numerical results on the knockdown factor are fitted to an empirical, albeit general, functional form that may be used as robust design guideline for the critical buckling conditions of pressurized spherical shells.

John W. Hutchinson

Papers

Mode III effects on interface delamination

Localization in spherical shell buckling

On optimal arches

Theory of Elasticity

Technical Brief: Knockdown Factor for the Buckling of Spherical Shells Containing Large-Amplitude Geometric Defects