J
Jon D. Larson
Researcher at St. Jude Children's Research Hospital
Publications - 31
Citations - 2746
Jon D. Larson is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Morpholino & Zebrafish. The author has an hindex of 18, co-authored 28 publications receiving 2484 citations. Previous affiliations of Jon D. Larson include University of Minnesota.
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Journal ArticleDOI
p53 Activation by Knockdown Technologies
Mara E. Robu,Jon D. Larson,Aidas Nasevicius,Aidas Nasevicius,Soraya Beiraghi,Charles Brenner,Steven A. Farber,Stephen C. Ekker +7 more
TL;DR: It is shown here that MO off-targeting results in induction of a p53-dependent cell death pathway, and p53 inhibition could potentially be applicable to other systems to suppress off- target effects caused by other knockdown technologies.
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Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant.
TL;DR: The zebrafish serves as a quality model for the study of conserved vertebrate angiogenesis processes during embryonic development and demonstrates a fundamental distinction between VEGF‐A requirements for axial and intersegmental vascular structure specification.
Journal ArticleDOI
Morphant technology in model developmental systems
Stephen C. Ekker,Jon D. Larson +1 more
TL;DR: Morpholino phosphorodiamidate oligonucleotides are synthetic DNA analogues with some highly favorable properties as in vivo gene targeting tools and are now being used for functional genomics applications, particularly in systems not amenable to standard genetic approaches.
Journal ArticleDOI
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.
Ying Wang,Mark S. Kaiser,Jon D. Larson,Aidas Nasevicius,Karl J. Clark,Shannon A. Wadman,Sharon E. Roberg-Perez,Stephen C. Ekker,Perry B. Hackett,Maura McGrail,Jeffrey J. Essner +10 more
TL;DR: In vivo imaging of living zebrafish embryos expressing fluorescent fusion proteins of β-Actin, α-Catenin, and the ERM family member Moesin1 is used to define a novel cord hollowing process that occurs during the initial stages of tubulogenesis in intersegmental vessels (ISVs) in the embryo.
Journal ArticleDOI
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.
Jon D. Larson,Lawryn H. Kasper,Barbara S. Paugh,Hongjian Jin,Gang Wu,Chang-Hyuk Kwon,Yiping Fan,Timothy I. Shaw,Andre B. Silveira,Chunxu Qu,Raymond Xu,Xiaoyan Zhu,Junyuan Zhang,Helen R. Russell,Jennifer L. Peters,David Finkelstein,Beisi Xu,Tong Lin,Christopher L. Tinkle,Zoltan Patay,Arzu Onar-Thomas,Stanley Pounds,Peter J. McKinnon,David W. Ellison,Jinghui Zhang,Suzanne J. Baker +25 more
TL;DR: Genetically engineered inducible mice were generated and it was shown that H3.3 K27M enhanced neural stem cell self-renewal while preserving regional identity and upregulated genes were enriched for those encoding homeodomain transcription factors.