L
Lawryn H. Kasper
Researcher at St. Jude Children's Research Hospital
Publications - 39
Citations - 5871
Lawryn H. Kasper is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: CREB-binding protein & Epigenetics. The author has an hindex of 23, co-authored 37 publications receiving 5126 citations.
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Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Journal ArticleDOI
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Laura Pasqualucci,David Dominguez-Sola,Annalisa Chiarenza,Giulia Fabbri,Adina Grunn,Vladimir Trifonov,Lawryn H. Kasper,Stephanie Lerach,Hongyan Tang,Jing Ma,Davide Rossi,Amy Chadburn,Vundavalli V. Murty,Charles G. Mullighan,Gianluca Gaidano,Raul Rabadan,Paul K. Brindle,Riccardo Dalla-Favera +17 more
TL;DR: The results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin’s lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms.
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Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation
Qihuang Jin,Li Rong Yu,Lifeng Wang,Zhijing Zhang,Lawryn H. Kasper,Ji-Eun Lee,Chaochen Wang,Paul K. Brindle,Sharon Y.R. Dent,Kai Ge +9 more
TL;DR: The results highlight the substrate and site specificities of HATs in cells, demonstrate the distinct roles of GCN5/PCAF‐ and CBP/p300‐mediated histone acetylations in gene activation, and suggest an important role of CBP/(p300)‐mediated H3K18/27ac in NR‐dependent transcription.
Journal ArticleDOI
CREBBP mutations in relapsed acute lymphoblastic leukaemia
Charles G. Mullighan,Jinghui Zhang,Lawryn H. Kasper,Stephanie Lerach,Debbie Payne-Turner,Letha A. Phillips,Susan L. Heatley,Linda Holmfeldt,J. Racquel Collins-Underwood,Jing Ma,Kenneth H. Buetow,Ching-Hon Pui,Sharyn D. Baker,Paul K. Brindle,James R. Downing +14 more
TL;DR: Analysis of an extended cohort of 71 diagnosis–relapse cases and 270 acute leukaemia cases that did not relapse found that 18.3% of relapse cases had sequence or deletion mutations of CREBBP, which encodes the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CREBBP).
Journal ArticleDOI
CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity
Lawryn H. Kasper,Paul K. Brindle,Catherine A. Schnabel,Colin E. J. Pritchard,Michael L. Cleary,Jan M. van Deursen +5 more
TL;DR: The results suggest that NUP98-HOXA9 chimeras are aberrant transcription factors that deregulate HOX-responsive genes through the transcriptional activation properties of nucleoporin-specific FG repeats that recruit CBP/p300.