M
Mara E. Robu
Researcher at University of Minnesota
Publications - 3
Citations - 1326
Mara E. Robu is an academic researcher from University of Minnesota. The author has contributed to research in topics: Morpholino & Zebrafish. The author has an hindex of 3, co-authored 3 publications receiving 1260 citations.
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Journal ArticleDOI
p53 Activation by Knockdown Technologies
Mara E. Robu,Jon D. Larson,Aidas Nasevicius,Aidas Nasevicius,Soraya Beiraghi,Charles Brenner,Steven A. Farber,Stephen C. Ekker +7 more
TL;DR: It is shown here that MO off-targeting results in induction of a p53-dependent cell death pathway, and p53 inhibition could potentially be applicable to other systems to suppress off- target effects caused by other knockdown technologies.
Journal ArticleDOI
WNT5A mutations in patients with autosomal dominant Robinow syndrome.
Anthony D. Person,Soraya Beiraghi,Christine M. Sieben,Spencer Hermanson,Ann N. Neumann,Mara E. Robu,J. Robert Schleiffarth,Charles J. Billington,Hans van Bokhoven,Jeannette A.M. Hoogeboom,Juliana F. Mazzeu,Anna Petryk,Lisa A. Schimmenti,Han G. Brunner,Stephen C. Ekker,Jamie L. Lohr +15 more
TL;DR: It is shown that two different missense mutations in WNT5A, which result in amino acid substitutions of highly conserved cysteines, are associated with autosomal dominant Robinow syndrome, and that proper formation and growth of these structures is sensitive to variations in W NT5A function.
Journal ArticleDOI
Genome-Wide Reverse Genetics Framework to Identify Novel Functions of the Vertebrate Secretome
Michael A. Pickart,Eric W. Klee,Aubrey L. Nielsen,Sridhar Sivasubbu,Eric M. Mendenhall,Brent R. Bill,Eleanor Chen,Craig E. Eckfeldt,Michelle N. Knowlton,Mara E. Robu,Jon D. Larson,Yun Deng,Lisa A. Schimmenti,Lynda B. M. Ellis,Catherine M. Verfaillie,Matthias Hammerschmidt,Steven A. Farber,Stephen C. Ekker +17 more
TL;DR: This study provides a framework utilizing zebrafish for the systematic assignment of biological function in a vertebrate genome with a notably higher rate of gene function annotation than the 2%–3% estimate from random gene mutagenesis studies.