Jonas Koeppel

TL;DR: It is demonstrated that chemical alteration of surface-exposed moieties can confer gain-of-function glue properties to an inhibitor, and this is proposed as a broader strategy through which target-binding molecules could be converted into molecular glues.

TL;DR: The findings demonstrate that a small molecule can induce polymerization coupled to highly specific protein degradation, which in the case of BCL6 leads to superior pharmacological activity, creating new avenues for the development of therapeutics and synthetic biology.

TL;DR: Most mutations were caused by ultraviolet (UV) light, but mutational signature analysis suggested differences in DNA repair processes between sites, and analysis of hair follicles showed mutations in the upper follicle resembled adjacent skin, but the lower follicle was sparsely mutated.

TL;DR: Protective CD8+ T cell responses in HSAN-I patient PBMCs and Sptlc2-deficient mice were restored by supplementing with sphingolipids and pharmacologically inhibiting ER stress-induced cell death, indicating that SPTLC2 underpins protective immunity by translating extracellular stimuli into intracellular anabolic signals and antagonizes ER stress to promote T-cell metabolic fitness.

TL;DR: In this article , the authors designed a library of 3,604 sequences of various lengths and measured the frequency of their insertion into four genomic sites in three human cell lines, using different prime editor systems in varying DNA repair contexts.