J
Jessica Mwinyi
Researcher at Uppsala University
Publications - 65
Citations - 2514
Jessica Mwinyi is an academic researcher from Uppsala University. The author has contributed to research in topics: DNA methylation & Migraine. The author has an hindex of 19, co-authored 56 publications receiving 2020 citations. Previous affiliations of Jessica Mwinyi include University of Zurich.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans
Luc Biedermann,Jonas Zeitz,Jessica Mwinyi,Eveline Sutter-Minder,Ateequr Rehman,Stephan J. Ott,Claudia Steurer-Stey,Anja Frei,Pascal Frei,Michael Scharl,Martin J. Loessner,Stephan R. Vavricka,Michael Fried,Stefan Schreiber,Markus Schuppler,Gerhard Rogler +15 more
TL;DR: The results indicate that smoking is an environmental factor modulating the composition of human gut microbiota, suggesting a potential pathogenetic link between weight gain and smoking cessation and giving rise to a potential association of smoking status and the course of IBD.
Journal ArticleDOI
Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study.
Luc Biedermann,Jessica Mwinyi,Michael Scharl,Pascal Frei,Jonas Zeitz,Gerd A. Kullak-Ublick,Stephan R. Vavricka,Michael Fried,Achim Weber,Hans-Ulrich Humpf,Simone Peschke,Alexander Jetter,Gerhard Krammer,Gerhard Rogler +13 more
TL;DR: This is the first report on the promising therapeutic potential of a standardized anthocyanin-rich bilberry preparation in UC in humans and results clearly indicate a therapeutic Potential of bilberries in UC.
Journal ArticleDOI
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.
Michael Scharl,Jessica Mwinyi,Anne Fischbeck,Katharina Leucht,Jyrki J. Eloranta,Joba M. Arikkat,Theresa Pesch,Silvia Kellermeier,Alma Mair,Gerd A. Kullak-Ublick,Kaspar Truninger,Faiza Noreen,Jaroslaw Regula,Pawel Gaj,Valérie Pittet,Christoph Mueller,Claudia Hofmann,Michael Fried,Declan F. McCole,Gerhard Rogler +19 more
TL;DR: These findings not only provide key insights into the effects of a functional mutation on a clinically relevant gene, but also reveal how such a mutation could contribute to the onset of disease.
Journal ArticleDOI
Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease
Jyrki J. Eloranta,Christa Wenger,Jessica Mwinyi,Christian Hiller,Christoph Gubler,Stephan R. Vavricka,Michael Fried,Gerd A. Kullak-Ublick +7 more
TL;DR: This study adds DBP to the list of potential genes that contribute to the complex genetic etiology of IBD, and further emphasizes the association between vitamin D homeostasis and intestinal inflammation.