J
Jonathan E. Kolitz
Researcher at North Shore University Hospital
Publications - 91
Citations - 8719
Jonathan E. Kolitz is an academic researcher from North Shore University Hospital. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 33, co-authored 91 publications receiving 8363 citations. Previous affiliations of Jonathan E. Kolitz include North Shore-LIJ Health System & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Tarun Wasil,Franco Fais,Franco Fais,Franco Fais,Fabio Ghiotto,Fabio Ghiotto,Fabio Ghiotto,Angelo Valetto,Angelo Valetto,Angelo Valetto,Steven L. Allen,Steven L. Allen,Steven L. Allen,Aby Buchbinder,Aby Buchbinder,Aby Buchbinder,Daniel R. Budman,Daniel R. Budman,Daniel R. Budman,Klaus Dittmar,Klaus Dittmar,Klaus Dittmar,Jonathan E. Kolitz,Jonathan E. Kolitz,Jonathan E. Kolitz,Stuart M. Lichtman,Stuart M. Lichtman,Stuart M. Lichtman,Philip Schulman,Philip Schulman,Philip Schulman,Vincent Vinciguerra,Vincent Vinciguerra,Vincent Vinciguerra,Kanti R. Rai,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Manlio Ferrarini,Manlio Ferrarini,Nicholas Chiorazzi,Nicholas Chiorazzi,Nicholas Chiorazzi +45 more
TL;DR: In this paper, cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V(H) and V(L) gene sequences were available.
Journal ArticleDOI
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.
Bradley T. Messmer,Davorka Messmer,Steven L. Allen,Steven L. Allen,Jonathan E. Kolitz,Jonathan E. Kolitz,Prasad Kudalkar,Prasad Kudalkar,Denise Cesar,Elizabeth Murphy,Prasad Koduru,Prasad Koduru,Manlio Ferrarini,Simona Zupo,Giovanna Cutrona,Rajendra N. Damle,Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Kanti R. Rai,Kanti R. Rai,Marc K. Hellerstein,Marc K. Hellerstein,Nicholas Chiorazzi,Nicholas Chiorazzi +24 more
TL;DR: B-CLL is not a static disease that results simply from accumulation of long-lived lymphocytes, Rather, it is a dynamic process composed also of cells that proliferate and die, often at appreciable levels, the extent to which this turnover occurs has not been previously appreciated.
Journal ArticleDOI
Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study
Peter Paschka,Guido Marcucci,Amy S. Ruppert,Krzysztof Mrózek,Hankui Chen,Rick A. Kittles,Tamara Vukosavljevic,Danilo Perrotti,James W. Vardiman,Andrew J. Carroll,Jonathan E. Kolitz,Richard A. Larson,Clara D. Bloomfield +12 more
TL;DR: It is reported for the first time thatmutKIT, and particularly mutKIT17, confer higher relapse risk, and both mutK IT17 and mutKit8 appear to adversely affect OS in AML with inv(16).
Journal ArticleDOI
Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
Bradley T. Messmer,Emilia Albesiano,Dimitar G. Efremov,Fabio Ghiotto,Fabio Ghiotto,Steven L. Allen,Jonathan E. Kolitz,Robin Foà,Rajendra N. Damle,Franco Fais,Davorka Messmer,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +14 more
TL;DR: Five sets of patients with strikingly similar B cell antigen receptors arising from the use of common H and L chain V region gene segments are described, implying a much more striking degree of structural restriction of the entire BCR and a much higher frequency of receptor sharing among patients than appreciated previously.
Journal ArticleDOI
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes.
Rajendra N. Damle,Fabio Ghiotto,Angelo Valetto,Emilia Albesiano,Franco Fais,Xiao-Jie Yan,Cristina Sison,Steven L. Allen,Jonathan E. Kolitz,Philip Schulman,Vincent Vinciguerra,Petra Budde,Jürgen Frey,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +15 more
TL;DR: The findings imply that the leukemic cells from all B-CLL cases (irrespective of V gene mutations) exhibit features of activated and of antigen-experienced B lymphocytes and that the B- CLL cells that differ in immunoglobulin V genotype may have different antigen-encounter histories.