M
Manlio Ferrarini
Researcher at University of Genoa
Publications - 239
Citations - 13576
Manlio Ferrarini is an academic researcher from University of Genoa. The author has contributed to research in topics: Chronic lymphocytic leukemia & Antigen. The author has an hindex of 51, co-authored 232 publications receiving 12934 citations. Previous affiliations of Manlio Ferrarini include National Cancer Research Institute.
Papers
More filters
Journal ArticleDOI
Chronic lymphocytic leukemia.
TL;DR: From the Institute for Medical Research, North Shore–LIJ Health System (N.R.R.), and the Departments of Medicine, North shore University Hospital, Manhasset, N.Y. (K.C., K.R.) and the Dipartimento di Oncologia Clinica e Sperimentale, Universitá di Genova (M.F.).
Journal ArticleDOI
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
Franco Fais,Fabio Ghiotto,Shiori Hashimoto,Brian Sellars,Angelo Valetto,Steven L. Allen,Philip Schulman,Vincent Vinciguerra,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Guillaume Dighiero,Harry W. Schroeder,Manlio Ferrarini,Nicholas Chiorazzi +14 more
TL;DR: These data suggest that many B-CLL cells have been previously stimulated, placing them in the "experienced" or "memory" CD5(+) B cell subset.
Journal ArticleDOI
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.
Bradley T. Messmer,Davorka Messmer,Steven L. Allen,Steven L. Allen,Jonathan E. Kolitz,Jonathan E. Kolitz,Prasad Kudalkar,Prasad Kudalkar,Denise Cesar,Elizabeth Murphy,Prasad Koduru,Prasad Koduru,Manlio Ferrarini,Simona Zupo,Giovanna Cutrona,Rajendra N. Damle,Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Kanti R. Rai,Kanti R. Rai,Marc K. Hellerstein,Marc K. Hellerstein,Nicholas Chiorazzi,Nicholas Chiorazzi +24 more
TL;DR: B-CLL is not a static disease that results simply from accumulation of long-lived lymphocytes, Rather, it is a dynamic process composed also of cells that proliferate and die, often at appreciable levels, the extent to which this turnover occurs has not been previously appreciated.
Journal ArticleDOI
Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
Bradley T. Messmer,Emilia Albesiano,Dimitar G. Efremov,Fabio Ghiotto,Fabio Ghiotto,Steven L. Allen,Jonathan E. Kolitz,Robin Foà,Rajendra N. Damle,Franco Fais,Davorka Messmer,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +14 more
TL;DR: Five sets of patients with strikingly similar B cell antigen receptors arising from the use of common H and L chain V region gene segments are described, implying a much more striking degree of structural restriction of the entire BCR and a much higher frequency of receptor sharing among patients than appreciated previously.
Journal ArticleDOI
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes.
Rajendra N. Damle,Fabio Ghiotto,Angelo Valetto,Emilia Albesiano,Franco Fais,Xiao-Jie Yan,Cristina Sison,Steven L. Allen,Jonathan E. Kolitz,Philip Schulman,Vincent Vinciguerra,Petra Budde,Jürgen Frey,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +15 more
TL;DR: The findings imply that the leukemic cells from all B-CLL cases (irrespective of V gene mutations) exhibit features of activated and of antigen-experienced B lymphocytes and that the B- CLL cells that differ in immunoglobulin V genotype may have different antigen-encounter histories.