A
Angelo Valetto
Researcher at University of Pisa
Publications - 73
Citations - 5043
Angelo Valetto is an academic researcher from University of Pisa. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 16, co-authored 65 publications receiving 4807 citations. Previous affiliations of Angelo Valetto include New York University & North Shore-LIJ Health System.
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Journal ArticleDOI
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Tarun Wasil,Franco Fais,Franco Fais,Franco Fais,Fabio Ghiotto,Fabio Ghiotto,Fabio Ghiotto,Angelo Valetto,Angelo Valetto,Angelo Valetto,Steven L. Allen,Steven L. Allen,Steven L. Allen,Aby Buchbinder,Aby Buchbinder,Aby Buchbinder,Daniel R. Budman,Daniel R. Budman,Daniel R. Budman,Klaus Dittmar,Klaus Dittmar,Klaus Dittmar,Jonathan E. Kolitz,Jonathan E. Kolitz,Jonathan E. Kolitz,Stuart M. Lichtman,Stuart M. Lichtman,Stuart M. Lichtman,Philip Schulman,Philip Schulman,Philip Schulman,Vincent Vinciguerra,Vincent Vinciguerra,Vincent Vinciguerra,Kanti R. Rai,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Manlio Ferrarini,Manlio Ferrarini,Nicholas Chiorazzi,Nicholas Chiorazzi,Nicholas Chiorazzi +45 more
TL;DR: In this paper, cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V(H) and V(L) gene sequences were available.
Journal ArticleDOI
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
Franco Fais,Fabio Ghiotto,Shiori Hashimoto,Brian Sellars,Angelo Valetto,Steven L. Allen,Philip Schulman,Vincent Vinciguerra,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Guillaume Dighiero,Harry W. Schroeder,Manlio Ferrarini,Nicholas Chiorazzi +14 more
TL;DR: These data suggest that many B-CLL cells have been previously stimulated, placing them in the "experienced" or "memory" CD5(+) B cell subset.
Journal ArticleDOI
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes.
Rajendra N. Damle,Fabio Ghiotto,Angelo Valetto,Emilia Albesiano,Franco Fais,Xiao-Jie Yan,Cristina Sison,Steven L. Allen,Jonathan E. Kolitz,Philip Schulman,Vincent Vinciguerra,Petra Budde,Jürgen Frey,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +15 more
TL;DR: The findings imply that the leukemic cells from all B-CLL cases (irrespective of V gene mutations) exhibit features of activated and of antigen-experienced B lymphocytes and that the B- CLL cells that differ in immunoglobulin V genotype may have different antigen-encounter histories.
Journal ArticleDOI
Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients.
Monica Colombo,Mariella Dono,Paola Gazzola,Silvio Roncella,Angelo Valetto,Nicholas Chiorazzi,Giovanni Luigi Mancardi,Manlio Ferrarini +7 more
TL;DR: The data suggest that in MS there is a compartmentalized clonal expansion and no intraclonal diversification could be observed even using VH3 gene-specific PCR methodologies.
Journal ArticleDOI
Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
Fabio Ghiotto,Franco Fais,Angelo Valetto,Emilia Albesiano,Shiori Hashimoto,Mariella Dono,Hideyuki Ikematsu,Steven L. Allen,Jonathan E. Kolitz,Kanti R. Rai,Marco Nardini,Anna Tramontano,Manlio Ferrarini,Nicholas Chiorazzi +13 more
TL;DR: The findings suggest that the B lymphocytes that gave rise to five IgG(+) B-CLL cells were selected for this unique BCR structure, and that these BCRs could bind the same antigenic epitope.