Ting Jia Fan

TL;DR: High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10–deficient (Il10−/−) mice, suggesting that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities.

TL;DR: Chronic intestinal inflammation causes functional alterations in gene expression in commensal gut bacterium (E coli NC101) and further studies of these expression patterns might identify therapeutic targets for patients with inflammatory bowel diseases.

TL;DR: GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses.

TL;DR: B. theta induces colitis in HLA-B27 Tg rats, which is associated with regulation of bacterial genes in metabolic and nutrient binding pathways that may affect host immune responses, and the identification of novel microbial targets for IBD therapies.

TL;DR: According to real‐time PCR, exposure of mice to CO results in changes in enteric bacterial composition and increases E. coli chuS expression in IL‐10 deficient mice, and CO alters the composition of the commensal intestinal microbiota and expands populations of E. Escherichia coli that harbor the chUS gene.