Jorge Kageyama

TL;DR: It is found that liver bud hepatoblasts diverge from the two-dimensional lineage, and express epithelial migration signatures characteristic of organ budding, and a striking correspondence between the three-dimensional liver bud and fetal liver cells is found.

TL;DR: These findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions and epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress.

TL;DR: Transgenic axolotl strains in which descendants of distinct adult cell types can be labeled, tracked, and isolated during the regenerative process provide an opportunity to understand how particular cell lineages progress during blastema formation and subsequent limb regrowth.

TL;DR: It is shown that successful direct reprogramming of adult human brain pericytes into functional iNs by Ascl1 and Sox2 encompasses transient activation of a neural stem cell-like gene expression program that precedes bifurcation into distinct neuronal lineages.

TL;DR: A novel method for the computational design of protein-small ligand binding named PocketOptimizer that uses a receptor-ligand scoring function to estimate the binding free energy between protein and ligand and introduces a much needed benchmark data set for the comparison of affinities of mutant binding pockets.