http://ssu.ac.ir/cms/fileadmin/user_upload/Mtahghighat/tfood/ARTICLES/koliat/Natural_products_as_antimicrobial_agents.pdf

Natural products as antimicrobial agents

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.

/pdf/the-therapeutic-potential-of-apigenin-3loarvjp93.pdf

The Therapeutic Potential of Apigenin.

Natural bioactive compounds include a broad diversity of structures and functionalities that provide an excellent pool of molecules for the production of nutraceuticals, functional foods, and food additives. Some of those compounds can be found in nature at high concentration such as polyphenols but others can only be found at very low levels, so that massive harvesting is needed to obtain sufficient amounts, and their structural diversity and complexity make chemical synthesis unprofitable. The inherent difficulties in screening and producing these compounds have led to the development of advanced technologies. The commonly used methods for their extraction are the conventional liquid–liquid or solid–liquid extraction and the advanced include pressurized-liquid extraction, subcritical and supercritical extractions, and microwave- and ultrasound-assisted extractions. In addition, these extraction techniques have been improved with previous steps (enzyme-and instant controlled pressure drop-assisted extractions) which help to release the compounds from the matrix. These technologies could provide in the next few years an innovative approach to increase the production of specific compounds for use as nutraceuticals or as ingredients in the design of functional foods.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/1541-4337.12005

Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview

http://sgpwe.izt.uam.mx/files/users/uami/jaislocr/QUIMICA_DE_ALIMENTOS/potencial_de_pigmentos_frutas_exoticas.pdf

Agro-industrial potential of exotic fruit byproducts as a source of food additives

Quantification of bioactive compounds in pulps and by-products of tropical fruits from Brazil

Effect of maturity stage on the content of fatty acids and antioxidant activity of 'Hass' avocado.

Tropical fruits production, trade and consumption have increased significantly due to their attractive sensory and nutrimental properties; nevertheless, their highly perishable nature limits their postharvest life. Postharvest treatments have been used to preserve quality of fresh produce and have been focused mainly on preserving freshness and avoid microbial growth. However, an improvement on the antioxidant system as a secondary response under certain adverse environmental and stress conditions has been observed, including some types of stress used as postharvest treatments. This review focuses on analyzing and proposing some possible mechanisms induced by postharvest treatments affecting the antioxidant status of treated tropical fruits.

Improvement of the antioxidant status of tropical fruits as a secondary response to some postharvest treatments

Inhibition of human α-amylase by dietary polyphenols

Transient hyperglycaemia is a risk factor for type 2 diabetes and endothelial dysfunction, especially in subjects with impaired glucose tolerance. Nutritional interventions and strategies for controlling postprandial overshoot of blood sugars are considered key in preventing progress to the disease state. We have identified apigenin-7-O-glucoside, apigenin, and (Z) and (E)-2-hydroxy-4-methoxycinnamic acid glucosides as the active (poly)phenols in Chamomile (Matricaria recutita) able to modulate carbohydrate digestion and absorption in vitro as assessed by inhibition of α-amylase and maltase activities. The latter two compounds previously mistakenly identified as ferulic acid hexosides were purified and characterised and studied for their contribution to the overall bioactivity of chamomile. Molecular docking studies revealed that apigenin and cinnamic acids present totally different poses in the active site of human α-amylase. In differentiated Caco-2/TC7 cell monolayers, apigenin-7-O-glucoside and apigenin strongly inhibited D-[U-14C]-glucose and D-[U-14C]-sucrose transport, and less effectively D-[U-14C]-fructose transport. Inhibition of D-[U-14C]-glucose transport by apigenin was stronger under Na+-depleted conditions, suggesting interaction with the GLUT2 transporter. Competitive binding studies with molecular probes indicate apigenin interacts primarily at the exofacial-binding site of GLUT2. Taken together, the individual components of Chamomile are promising agents for regulating carbohydrate digestion and sugar absorption at the site of the gastrointestinal tract.

/pdf/acute-metabolic-actions-of-the-major-polyphenols-in-9szgtd34hb.pdf

Acute metabolic actions of the major polyphenols in chamomile: an in vitro mechanistic study on their potential to attenuate postprandial hyperglycaemia.

Jose A. Villa-Rodriguez

Papers

Agro-industrial potential of exotic fruit byproducts as a source of food additives

Effect of maturity stage on the content of fatty acids and antioxidant activity of 'Hass' avocado.

Improvement of the antioxidant status of tropical fruits as a secondary response to some postharvest treatments

Inhibition of human α-amylase by dietary polyphenols

Acute metabolic actions of the major polyphenols in chamomile: an in vitro mechanistic study on their potential to attenuate postprandial hyperglycaemia.