M
Marc L. Seal
Researcher at University of Melbourne
Publications - 195
Citations - 9029
Marc L. Seal is an academic researcher from University of Melbourne. The author has contributed to research in topics: White matter & Diffusion MRI. The author has an hindex of 43, co-authored 185 publications receiving 7586 citations. Previous affiliations of Marc L. Seal include Florey Institute of Neuroscience and Mental Health & University of Cambridge.
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Journal ArticleDOI
Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.
Sagnik Bhattacharyya,Paul D. Morrison,Paolo Fusar-Poli,Paolo Fusar-Poli,Rocio Martin-Santos,Stefan Borgwardt,Stefan Borgwardt,Toby T. Winton-Brown,Chiara Nosarti,Colin M O' Carroll,Marc L. Seal,Paul Allen,Mitul A. Mehta,James M. Stone,Nigel Tunstall,Vincent Giampietro,Shitij Kapur,Robin M. Murray,Antonio Waldo Zuardi,José Alexandre de Souza Crippa,Zerrin Atakan,Philip McGuire +21 more
TL;DR: Functional magnetic resonance imaging in healthy volunteers found that Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ- 9- THC.
Journal ArticleDOI
Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group
Sinead Kelly,Sinead Kelly,Neda Jahanshad,Andrew Zalesky,Peter Kochunov,Ingrid Agartz,Ingrid Agartz,Clara Alloza,Ole A. Andreassen,Celso Arango,Nerisa Banaj,Sylvain Bouix,Chad A. Bousman,Chad A. Bousman,Chad A. Bousman,Rachel M. Brouwer,Jason M. Bruggemann,Juan R. Bustillo,Wiepke Cahn,V.D. Calhoun,V.D. Calhoun,Dara M. Cannon,Vaughan J. Carr,Stanley V. Catts,J. Chen,J. X. Chen,X. Chen,Chiara Chiapponi,Kl K. Cho,Valentina Ciullo,A. S. Corvin,Benedicto Crespo-Facorro,Vanessa Cropley,P. De Rossi,Covadonga M. Díaz-Caneja,Erin W. Dickie,Stefan Ehrlich,F. M. Fan,Joshua Faskowitz,Helena Fatouros-Bergman,L. Flyckt,L. Flyckt,Judith M. Ford,Jean-Paul Fouche,Masaki Fukunaga,Michael Gill,David C. Glahn,Randy L. Gollub,E. D. Goudzwaard,H. Guo,R.E. Gur,Ruben C. Gur,Tiril P. Gurholt,Ryota Hashimoto,Ryota Hashimoto,Sean N. Hatton,Frans Henskens,Frans Henskens,Derrek P. Hibar,Ian B. Hickie,L. E. Hong,Jiri Horacek,Jiri Horacek,Fleur M. Howells,Hilleke E. Hulshoff Pol,Craig L. Hyde,Dmitry Isaev,Assen Jablensky,Philip R. Jansen,Joost Janssen,Joost Janssen,Erik G. Jönsson,Erik G. Jönsson,L. A. Jung,René S. Kahn,Zora Kikinis,K. Liu,Paul Klauser,Paul Klauser,Paul Klauser,C. Knöchel,Marek Kubicki,Jim Lagopoulos,Carolyn D. Langen,Stephen M. Lawrie,Rhoshel K. Lenroot,Kelvin O. Lim,Carlos López-Jaramillo,Amanda E. Lyall,Amanda E. Lyall,Vincent A. Magnotta,René C.W. Mandl,Daniel H. Mathalon,R. W. McCarley,Simon McCarthy-Jones,Colm McDonald,Sarah McEwen,Andrew M. McIntosh,Tomas Melicher,Tomas Melicher,Raquelle I. Mesholam-Gately,Patricia T. Michie,Patricia T. Michie,Bryan J. Mowry,Bryon A. Mueller,Dominick T. Newell,Patricio O'Donnell,V. Oertel-Knöchel,Lena K. L. Oestreich,Sara A. Paciga,Christos Pantelis,Christos Pantelis,Christos Pantelis,Ofer Pasternak,Godfrey D. Pearlson,Gaia Romana Pellicano,Antonio Pereira,J. Pineda Zapata,F. Piras,Steven G. Potkin,Adrian Preda,P. E. Rasser,P. E. Rasser,David R. Roalf,R. Roiz,Annerine Roos,D. Rotenberg,Theodore D. Satterthwaite,Peter Savadjiev,Ulrich Schall,Ulrich Schall,Rodney J. Scott,Rodney J. Scott,Marc L. Seal,Larry J. Seidman,Larry J. Seidman,Larry J. Seidman,C. Shannon Weickert,C. Shannon Weickert,C. Shannon Weickert,Christopher D. Whelan,Martha E. Shenton,Martha E. Shenton,Jun Soo Kwon,Gianfranco Spalletta,Filip Spaniel,Filip Spaniel,Emma Sprooten,M. Stäblein,Dan J. Stein,Dan J. Stein,Suresh Sundram,Suresh Sundram,Y. Tan,S. Tan,S. Tang,H. S. Temmingh,Lars T. Westlye,Siren Tønnesen,Diana Tordesillas-Gutiérrez,Nhat Trung Doan,Jatin G. Vaidya,N.E.M. van Haren,Claudia D. Vargas,Daniela Vecchio,Dennis Velakoulis,Aristotle N. Voineskos,J. Q. Voyvodic,Zhen Wang,P. Wan,D. Wei,Thomas W. Weickert,Thomas W. Weickert,Thomas W. Weickert,Heather C. Whalley,Tonya White,Thomas J. Whitford,Joanne Wojcik,H. Xiang,H. Xiang,Z. Xie,H. Yamamori,F. Yang,Nailin Yao,G. Zhang,Jingjing Zhao,Jingjing Zhao,T.G.M. van Erp,Jessica A. Turner,Paul M. Thompson,Paul M. Thompson,Gary Donohoe +191 more
TL;DR: The present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide, and is believed to be the first ever large-scale coordinated study of WM microstructural differences in schizophrenia.
Journal ArticleDOI
Disrupted Axonal Fiber Connectivity in Schizophrenia
Andrew Zalesky,Alex Fornito,Alex Fornito,Marc L. Seal,Luca Cocchi,Carl-Fredrik Westin,Edward T. Bullmore,Gary F. Egan,Christos Pantelis +8 more
TL;DR: Evidence of widespread dysconnectivity in white-matter connectional architecture in a large sample of patients with schizophrenia is presented, pointing to a multifaceted pathophysiology in schizophrenia encompassing axonal as well as putative synaptic mechanisms.
Journal ArticleDOI
Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing.
Paolo Fusar-Poli,José Alexandre de Souza Crippa,Sagnik Bhattacharyya,Stefan Borgwardt,Paul Allen,Rocío Martín-Santos,Marc L. Seal,Simon Surguladze,Colin O'Carrol,Zerrin Atakan,Antonio Waldo Zuardi,Philip McGuire +11 more
TL;DR: Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces, and the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.
Journal ArticleDOI
Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis.
Emre Bora,Alex Fornito,Joaquim Radua,Mark Walterfang,Marc L. Seal,Stephen J. Wood,Stephen J. Wood,Murat Yücel,Dennis Velakoulis,Christos Pantelis +9 more
TL;DR: The meta-analyses revealed overlapping GM and WM structural findings in schizophrenia, characterized by bilateral anterior cortical, limbic and subcortical GM abnormalities, and WM changes in regions including tracts that connect these structures within and between hemispheres.