J
Joseph Kirma
Researcher at University of Michigan
Publications - 5
Citations - 129
Joseph Kirma is an academic researcher from University of Michigan. The author has contributed to research in topics: Psoriasis & Transcriptome. The author has an hindex of 3, co-authored 5 publications receiving 43 citations.
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Journal ArticleDOI
Contribution of plasma cells and B-cells to hidradenitis suppurativa pathogenesis.
Johann E. Gudjonsson,Lam C. Tsoi,Feiyang Ma,Allison C. Billi,K R van Straalen,Allard R. J. V. Vossen,H.H. van der Zee,Paul W. Harms,Rachael Wasikowski,Christine M. Yee,Syed Monem Rizvi,Xianying Xing,Enze Xing,Olesya Plazyo,Chang Zeng,Matthew Patrick,Margaret M. Lowe,Richard E. Burney,Jeffrey H. Kozlow,Jill R. Cherry-Bukowiec,Yanyun Jiang,Joseph Kirma,Stephan Weidinger,Kelly C. Cushing,Michael Rosenblum,Celine C. Berthier,Amanda S. MacLeod,John J. Voorhees,Fei Wen,J. Michelle Kahlenberg,Emanual Michael Maverakis,Robert L. Modlin,Errol P. Prens +32 more
TL;DR: Preclinical evidence is provided to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS, with Bruton’s tyrosine kinase (BTK) and spleen tyrosinase (SYK) pathway activation as a central signal transduction network in HS.
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TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF.
Aaron denDekker,Frank M. Davis,Amrita Joshi,Sonya J. Wolf,Ronald M. Allen,Jay H Lipinski,Brenda Nguyen,Joseph Kirma,Dylan Nycz,Jennifer Bermick,Bethany B. Moore,Johann E. Gudjonsson,Steven L. Kunkel,Katherine A. Gallagher +13 more
TL;DR: This report is the first to define an important role for MOF in regulating macrophage-mediated inflammation in wound repair and identifies TNFα-inhibition as a potential therapy for the treatment of chronic inflammation in diabetic wounds.
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IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.
Shuai Shao,Shuai Shao,Lam C. Tsoi,William R. Swindell,Jiaoling Chen,Ranjitha Uppala,Allison C. Billi,Xianying Xing,Chang Zeng,Mrinal K. Sarkar,Rachael Wasikowski,Yanyun Jiang,Joseph Kirma,Jingru Sun,Olesya Plazyo,Gang Wang,Paul W. Harms,John J. Voorhees,Nicole L. Ward,Feiyang Ma,Matteo Pellegrini,Alexander A. Merleev,Bethany E. Perez White,Robert L. Modlin,Bogi Andersen,Emanual Michael Maverakis,Stephan Weidinger,J. Michelle Kahlenberg,Johann E. Gudjonsson +28 more
TL;DR: In this article, a member of the signaling complex downstream of IL-1 and IL-36, correlates positively with disease severity in both atopic dermatitis and psoriasis.
Journal ArticleDOI
Non-invasive tape-stripping with high-resolution RNA profiling effectively captures a pre-inflammatory state in nonlesional psoriatic skin.
Lam C. Tsoi,Xianying Xing,Enze Xing,Rachael Wasikowski,Shuai Shao,Chang Zeng,Olesya Plazyo,Joseph Kirma,Yanyung Jiang,Allison C. Billi,Mrinal K. Sarkar,Jessica L Turnier,Ranjitha Uppala,Kathleen M. Smith,Yolanda R. Helfrich,John J. Voorhees,Emanual Michael Maverakis,Robert L. Modlin,J. Michelle Kahlenberg,Victoria E. Scott,Johann E. Gudjonsson +20 more
TL;DR: In this paper, the authors compared different tape stripping technologies and full-thickness skin biopsy results of lesional and non-lesional psoriatic skin from the same patients, demonstrating that tape stripping with optimized high-resolution transcriptomic profiling can be used to effectively assess and characterize inflammatory responses in skin.
Journal ArticleDOI
Transcriptome mining and B cell depletion support a role for B cells in psoriasis pathophysiology
Atrin Toussi,Alexander A. Merleev,Virginia R. Barton,Stephanie T. Le,Alina I. Marusina,Guillaume Luxardi,Joseph Kirma,Xianying Xing,Iannis E. Adamopoulos,Maxwell A Fung,Siba P. Raychaudhuri,Michiko Shimoda,Johann E. Gudjonsson,Emanual Michael Maverakis +13 more