Yanyun Jiang

TL;DR: The skin serves as the primary interface between the authors' body and the external environment and acts as a barrier against entry of physical agents, chemicals, and microbes and keratinocytes actively participate in maintaining tissue homeostasis.

TL;DR: Preclinical evidence is provided to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS, with Bruton’s tyrosine kinase (BTK) and spleen tyrosinase (SYK) pathway activation as a central signal transduction network in HS.

TL;DR: In this article, a member of the signaling complex downstream of IL-1 and IL-36, correlates positively with disease severity in both atopic dermatitis and psoriasis.

TL;DR: Hcy significantly promoted the senescence of N2a cells with elevated β-catenin and Kelch like ECH-associated protein 1 (Keap1), but increased the interaction between Keap1 and Wilms tumor gene on X chromosome (WTX), but decreased β-Catenin-WTX interaction simultaneously.

TL;DR: The finding suggested that the levels of circulating bioactive IL-17A were associated with disease activity in psoriasis patients and the titers of ACAAs were not significantly altered nor correlated with disease severity, however, the functionality ofACAAs remains to be further demonstrated in vitro in future studies.