M
Margaret M. Lowe
Researcher at University of California, San Francisco
Publications - 29
Citations - 1986
Margaret M. Lowe is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 13, co-authored 26 publications receiving 1298 citations. Previous affiliations of Margaret M. Lowe include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
David Favre,Jeff E. Mold,Peter W. Hunt,Bittoo Kanwar,P'ng Loke,Lillian Seu,Jason D. Barbour,Margaret M. Lowe,Anura Jayawardene,Francesca T. Aweeka,Yong Huang,Daniel C. Douek,Jason M. Brenchley,Jeffrey N. Martin,Frederick Hecht,Steven G. Deeks,Joseph M. McCune +16 more
TL;DR: Patients with AIDS have fewer immune cells to defend against microbial invasion through the gut, a critical loss that may be caused by a tryptophan metabolite produced by other immune cells, and IDO1 inhibitors are being tested for their efficacy in interfering with this dangerous depletion of defenses.
Journal ArticleDOI
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
Niwa Ali,Niwa Ali,Bahar Zirak,Robert Rodriguez,Mariela L. Pauli,Hong-An Truong,Kevin Lai,Richard Ahn,Kaitlin Corbin,Margaret M. Lowe,Tiffany C. Scharschmidt,Keyon Taravati,Madeleine R. Tan,Roberto R. Ricardo-Gonzalez,Audrey Nosbaum,Marta Bertolini,Wilson Liao,Frank O. Nestle,Ralf Paus,George Cotsarelis,Abul K. Abbas,Michael Rosenblum +21 more
TL;DR: It is demonstrated that Tregs in skin play a major role in HF biology by promoting the function of HF SCs and expression of Jag1 facilitated HFSC function and efficient HF regeneration.
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Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Tiffany C. Scharschmidt,Kimberly S. Vasquez,Mariela L. Pauli,Elizabeth G. Leitner,Kevin Y. Chu,Hong-An Truong,Margaret M. Lowe,Robert Rodriguez,Niwa Ali,Zoltan Laszik,Justin L. Sonnenburg,Sarah E. Millar,Michael Rosenblum +12 more
TL;DR: HF morphogenesis, commensal microbe colonization, and local chemokine production work in concert to recruit Tregs into neonatal skin, thereby establishing this tissue Treg niche early in life.
Journal ArticleDOI
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization
Hsin-Wen Chang,Di Yan,Di Yan,Rasnik Singh,Rasnik Singh,J. Liu,Xueyan Lu,Xueyan Lu,Derya Ucmak,Derya Ucmak,Kristina Lee,Ladan Afifi,Ladan Afifi,Douglas Fadrosh,John Leech,Kimberly S. Vasquez,Margaret M. Lowe,Michael Rosenblum,Tiffany C. Scharschmidt,Susan V. Lynch,Wilson Liao +20 more
TL;DR: The results suggest that microbial communities on psoriatic skin is substantially different from those on healthy skin, and the psoriasis-associated skin microbiome has increased diversity and reduced stability compared to the healthy skin microbiome.
Journal ArticleDOI
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
Margaret M. Lowe,Jeff E. Mold,Bittoo Kanwar,Yong Huang,Alexander Louie,Michael P. Pollastri,Cuihua Wang,Gautam Patel,Diana G. Franks,Jennifer J. Schlezinger,David H. Sherr,Allen E. Silverstone,Mark E. Hahn,Joseph M. McCune +13 more
TL;DR: The ability of tryptophan metabolites to bind and activate the AHR and to increase IL-22 production in human T cells is characterized and a novel endogenous AHR agonist with potentially broad biological functions is defined.