P
Paul W. Harms
Researcher at University of Michigan
Publications - 148
Citations - 5080
Paul W. Harms is an academic researcher from University of Michigan. The author has contributed to research in topics: Merkel cell carcinoma & Merkel cell polyomavirus. The author has an hindex of 29, co-authored 115 publications receiving 3300 citations. Previous affiliations of Paul W. Harms include Tulane University & University of Alabama at Birmingham.
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Journal ArticleDOI
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
Heng Lin,Shuang Wei,Elaine M. Hurt,Michael D. Green,Lili Zhao,Linda Vatan,Wojciech Szeliga,Ronald Herbst,Paul W. Harms,Leslie A. Fecher,Pankaj Vats,Arul M. Chinnaiyan,Christopher D. Lao,Theodore S. Lawrence,Max S. Wicha,Junzo Hamanishi,Masaki Mandai,Ilona Kryczek,Weiping Zou +18 more
TL;DR: PD-L1–expressing dendritic cells and macrophages may mechanistically shape and therapeutically predict clinical efficacy of PD-L 1/PD-1 blockade.
Journal ArticleDOI
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Paul W. Harms,Pankaj Vats,Pankaj Vats,Monique Verhaegen,Dan R. Robinson,Yi-Mi Wu,Saravana M. Dhanasekaran,Nallasivam Palanisamy,Nallasivam Palanisamy,Javed Siddiqui,Xuhong Cao,Fengyun Su,Rui Wang,Hong Xiao,Hong Xiao,Lakshmi P. Kunju,Rohit Mehra,Rohit Mehra,Scott A. Tomlins,Douglas R. Fullen,Christopher K. Bichakjian,Timothy M. Johnson,Andrzej A. Dlugosz,Arul M. Chinnaiyan +23 more
TL;DR: Findings suggest a potential ontologic dichotomy in MCC, characterized by either viral-dependent or UV-dependent tumorigenic pathways.
Journal ArticleDOI
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis
Andrew Johnston,Xianying Xing,Liza Wolterink,Drew H. Barnes,Z. Yin,Z. Yin,Laura J. Reingold,J. Michelle Kahlenberg,Paul W. Harms,Johann E. Gudjonsson +9 more
TL;DR: Sustained activation of IL‐1 and IL‐36 in GPP is indicated, inducing neutrophil chemokine expression, infiltration, and pustule formation, suggesting that the IL-1/IL‐36 inflammatory axis is a potent driver of disease pathology in G PP.
Journal ArticleDOI
The biology and treatment of Merkel cell carcinoma: current understanding and research priorities
Paul W. Harms,Kelly L. Harms,Patrick S. Moore,James A. DeCaprio,Paul Nghiem,Michael K K Wong,Isaac Brownell +6 more
TL;DR: The availability of immune checkpoint inhibition has improved the outcomes of a subset of patients with MCC, although many unmet needs continue to exist, according to this Consensus Statement.