J
Joseph M. Pilewski
Researcher at University of Pittsburgh
Publications - 322
Citations - 17263
Joseph M. Pilewski is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Lung transplantation & Cystic fibrosis. The author has an hindex of 65, co-authored 285 publications receiving 15142 citations. Previous affiliations of Joseph M. Pilewski include Boston Children's Hospital & University of Pennsylvania.
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Journal ArticleDOI
Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro.
TL;DR: Evidence is provided that negatively charged moieties on the cell surface reduce the efficiency of adenovirus-mediated gene transfer, and that alteration of the charge interaction betweenadenoviruses and the cellsurface may improve the potential clinical application of these vectors.
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Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity.
Dimitra Mitsani,M. Hong Nguyen,Ryan K. Shields,Yoshiya Toyoda,Eun J. Kwak,Fernanda P. Silveira,Joseph M. Pilewski,Maria Crespo,Christian Bermudez,Jay K. Bhama,Cornelius J. Clancy +10 more
TL;DR: The troughs did not differ at the times of suspected drug-induced hepatotoxicity, central nervous system (CNS) toxicity, or nausea/vomiting and in the absence of toxicity, and Voriconazole prophylaxis was most effective at troughs of >1.5 μg/ml.
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Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules.
Horng Chin Yan,István Juhász,Joseph M. Pilewski,George F. Murphy,Meenhard Herlyn,Steven M. Albelda,Steven M. Albelda +6 more
TL;DR: The results indicate that the severe combined immunodeficient mouse/human skin transplant model provides a useful in vivo system in which to study human endothelium during the process of inflammation.
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Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function.
Steven T. Truschel,Wily G. Ruiz,Theodore Shulman,Joseph M. Pilewski,Tung-Tien Sun,Mark L. Zeidel,Gerard Apodaca +6 more
TL;DR: A primary cell culture model of rabbit uroepithelium that consists of an underlying cell layer that interacts with a collagen substratum, an intermediate cell layer, and an upper cell layer of large (25–100 μm) superficial cells should serve as a useful tool to explore normal uroEPithelial function as well as dysfunction as a result of disease.
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Adhesion Molecules in the Lung: An Overview
TL;DR: Several distinct cell adhesion molecule families have recently been identified and found to be important in the inflammatory response and for epithelial and endothelial homeostasis and their relevance for pulmonary structure and inflammation is discussed.