J
Joseph M. Pilewski
Researcher at University of Pittsburgh
Publications - 322
Citations - 17263
Joseph M. Pilewski is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Lung transplantation & Cystic fibrosis. The author has an hindex of 65, co-authored 285 publications receiving 15142 citations. Previous affiliations of Joseph M. Pilewski include Boston Children's Hospital & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis
Florencia McAllister,Adam C. Henry,James L. Kreindler,Patricia J. Dubin,Lauren Ulrich,Chad Steele,Jonathan D. Finder,Joseph M. Pilewski,Beatriz M. Carreno,Samuel J. Goldman,Jaana Pirhonen,Jay K. Kolls +11 more
TL;DR: It is shown that IL- 17R is localized to basal airway cells in human lung tissue, and functional IL-17R signaling occurs on the basolateral surface of human bronchial epithelial (HBE) cells.
Journal ArticleDOI
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
Wen Ning,Chaojun Li,Chaojun Li,Naftali Kaminski,Carol Feghali-Bostwick,Sean Alber,Yuanpu P. Di,Sherrie L. Otterbein,Ruiping Song,Shizu Hayashi,Zhihong Zhou,David J. Pinsky,Simon C. Watkins,Joseph M. Pilewski,Frank C. Sciurba,David G. Peters,James C. Hogg,Augustine M.K. Choi +17 more
TL;DR: This study represents the first comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers and reveals previously unreported candidate genes that may serve as potential molecular targets in COPD.
Journal ArticleDOI
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.
James B. Bruns,Marcelo D. Carattino,Shaohu Sheng,Ahmad B. Maarouf,Ora A. Weisz,Joseph M. Pilewski,Rebecca P. Hughey,Thomas R. Kleyman +7 more
TL;DR: It is reported that the serine protease prostasin further activates ENaC by inducing cleavage of the γ subunit at a site distal to the furin cleavage site, and the results suggest that multiple proteases cleave ENoC γSubunit subunits to fully activate the channel.
Journal ArticleDOI
High IFN-γ and low SLPI mark severe asthma in mice and humans
Mahesh Raundhal,Christina Morse,Anupriya Khare,Timothy B. Oriss,Jadranka Milosevic,John B. Trudeau,Rachael Huff,Joseph M. Pilewski,Fernando Holguin,Jay K. Kolls,Sally E. Wenzel,Prabir Ray,Anuradha Ray +12 more
TL;DR: It is determined that IFN-γ (Th1) immune responses are exacerbated in the airways of individuals with SA, with reduced Th2 and IL-17 responses, and a distinct immune response in SA characterized by a dysregulated IFn-γ/SLPI axis that affects lung function.
Journal ArticleDOI
Autoantibodies in patients with chronic obstructive pulmonary disease.
Carol Feghali-Bostwick,Aneal Gadgil,Leo E. Otterbein,Joseph M. Pilewski,Michael W. Stoner,Eva Csizmadia,Yingze Zhang,Frank C. Sciurba,Steven R. Duncan +8 more
TL;DR: IgG autoantibodies with avidity for pulmonary epithelium, and the potential to mediate cytotoxicity, are prevalent in patients with COPD and may be important in the etiology of this disease.