J
Joseph M. Pilewski
Researcher at University of Pittsburgh
Publications - 322
Citations - 17263
Joseph M. Pilewski is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Lung transplantation & Cystic fibrosis. The author has an hindex of 65, co-authored 285 publications receiving 15142 citations. Previous affiliations of Joseph M. Pilewski include Boston Children's Hospital & University of Pennsylvania.
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Journal ArticleDOI
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.
Marcelo D. Carattino,Shaohu Sheng,James B. Bruns,Joseph M. Pilewski,Rebecca P. Hughey,Thomas R. Kleyman +5 more
TL;DR: It is suggested that proteolysis of the α subunit activates ENaC by disassociating an inhibitory domain (αAsp-206-Arg-231) from its effector site within the channel complex.
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Comparison of an Aspergillus Real-time Polymerase Chain Reaction Assay With Galactomannan Testing of Bronchoalvelolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Lung Transplant Recipients
Me Linh Luong,Cornelius J. Clancy,Aniket Vadnerkar,Eun J. Kwak,Fernanda P. Silveira,Mark C. Wissel,Kevin J. Grantham,Ryan K. Shields,Maria Crespo,Joseph M. Pilewski,Yoshiya Toyoda,Steven B. Kleiboeker,Diana L. Pakstis,S. Reddy,Thomas J. Walsh,M. Hong Nguyen +15 more
TL;DR: A recently developed pan-Aspergillus PCR assay and GM testing of BAL fluid may facilitate the diagnosis of IPA after lung transplantation and may be useful in rapidly identifying the most common cause of IPA and a species that is intrinsically resistant to amphotericin B.
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De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation
Matthew R. Morrell,Joseph M. Pilewski,Cynthia J. Gries,Matthew R. Pipeling,Maria Crespo,Christopher R. Ensor,Samuel A. Yousem,Jonathan D'Cunha,Norihisa Shigemura,Christian Bermudez,John F. McDyer,Adriana Zeevi +11 more
TL;DR: Evidence is provided that dnDSA is associated with accelerated BOS kinetics and severity, as well as death due to BOS after lung transplantation, and the need for novel strategies to mitigate the increased risk of poor outcomes associated with dn DSA is underscored.
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Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: long-term survival.
Christian Bermudez,Prasad S. Adusumilli,Kenneth R. McCurry,Diana Zaldonis,Maria Crespo,Joseph M. Pilewski,Yoshiya Toyoda +6 more
TL;DR: Long-term survival of patients with primary graft dysfunction requiring ECMO (overall and weaned) was inferior to that of patients who did not require ECMO andExtracorporeal membrane oxygenation can provide acceptable support for PGD irrespective of the method used.
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UTP inhibits Na+ absorption in wild-type and ΔF508 CFTR-expressing human bronchial epithelia
TL;DR: It is concluded that increasing cellular Ca2+ induces a long-term inhibition of transepithelial Na+transport across normal and CF HBE at least partly due to downregulation of a basolateral membrane K+ conductance.