Joseph McPartlin

TL;DR: The purpose of this review is to provide an international expert opinion on the practical aspects of total homocysteine determinations in clinical practice and in the research setting and on the relevance of total Homocystinuria measurements as diagnostic or screening tests in several target populations.

TL;DR: The study shows that an abnormality in homocysteine metabolism, apparently related to methionine synthase, is present in many women who give birth to children with neural-tube defects and suggests that the most effective periconceptional prophylaxis to prevent neural- tube defects may require B 12 as well as folic acid.

TL;DR: A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.

TL;DR: The epidemiological, genetic, and animal evidence together indicate that the association between serum homocysteine level and ischemic heart disease (IHD) is likely to be causal.

TL;DR: A repeated serum folic acid response is likely to be found in many women complying with the advice to take 400 micrograms folic Acid/d to prevent the occurrence of neural tube defects, particularly in consumers in nontargeted populations of large amounts of fortified foods.