Joseph P. Tiano

TL;DR: A glucagon-like peptide-1 (GLP-1)-estrogen conjugate that has superior sex-independent efficacy over either of the individual hormones alone to correct obesity, hyperglycemia and dyslipidemia in mice is reported.

TL;DR: Why and how enhancing ER action in β cells without the undesirable effect of general oestrogen therapy is a therapeutic avenue to preserve functional β-cell mass in patients with diabetes mellitus are discussed.

TL;DR: Treating male Zucker diabetic fatty rats with E2 suppressed synthesis and accumulation of fatty acids and glycerolipids in islets and protected against β cell failure, suggesting that extranuclear ERs may be promising therapeutic targets to preventβ cell failure in T2D.

TL;DR: This study supports the importance of ERα in β cells as a regulator of insulin synthesis in vivo and finds that the extranuclear ERα interacts with the tyrosine kinase Src, which activates extracellular signal-regulated kinases1/2, to increase nuclear localization and binding to the insulin promoter of the transcription factor NeuroD1.

TL;DR: It is found that NTFs display a masculinized energy intake and ARC POMC expression and innervation as observed in CMs, which can be mimicked by neonatal exposure to the androgen receptor agonist dihydrotestosterone (DHT).