J
Joseph R. Winer
Researcher at University of California, Berkeley
Publications - 18
Citations - 1408
Joseph R. Winer is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 10 publications receiving 902 citations. Previous affiliations of Joseph R. Winer include Helen Wills Neuroscience Institute.
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Journal ArticleDOI
Sleep and Human Aging
TL;DR: Do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?
Journal ArticleDOI
Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?
Bryce A. Mander,Joseph R. Winer,William J. Jagust,William J. Jagust,Matthew P. Walker,Matthew P. Walker +5 more
TL;DR: A role for NREM sleep disruption as a novel factor linking cortical Aβ to impaired hippocampus-dependent memory consolidation and the possibility of sleep as a new treatment target in aging, affording preventative and therapeutic benefits is evaluated.
Journal ArticleDOI
Sleep as a potential biomarker of tau and β-amyloid burden in the human brain
Joseph R. Winer,Bryce A. Mander,Bryce A. Mander,Randolph F. Helfrich,Anne Maass,Anne Maass,Theresa M. Harrison,Suzanne L. Baker,Robert T. Knight,William J. Jagust,William J. Jagust,Matthew P. Walker,Matthew P. Walker +12 more
TL;DR: The present study reveals human sleep signatures that dissociably predict levels of brain tau and Aβ in older adults, and suggests that treating sleep deficiencies within decade-specific time windows may serve in delaying AD progression.
Journal ArticleDOI
18F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study
Daniel R. Schonhaut,Daniel R. Schonhaut,Daniel R. Schonhaut,Corey T. McMillan,Salvatore Spina,Bradford C. Dickerson,Andrew Siderowf,Michael D. Devous,Richard M. Tsai,Joseph R. Winer,David S. Russell,Irene Litvan,Erik D. Roberson,William W. Seeley,Lea T. Grinberg,Joel H. Kramer,Bruce L. Miller,Peter Pressman,Ilya M. Nasrallah,Suzanne L. Baker,Stephen N. Gomperts,Keith A. Johnson,Murray Grossman,William J. Jagust,Adam L. Boxer,Gil D. Rabinovici,Gil D. Rabinovici +26 more
TL;DR: Schonhaut et al. as mentioned in this paper compared in vivo 18 F-flortaucipir uptake in patients meeting clinical research criteria for PSP (n = 33) to normal controls and patients meeting criteria for Parkinson disease (PD; n = 26).
Journal ArticleDOI
Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years.
Joseph R. Winer,Bryce A. Mander,Samika Kumar,Mark Reed,Suzanne L. Baker,William J. Jagust,William J. Jagust,Matthew P. Walker,Matthew P. Walker +8 more
TL;DR: The data support the proposal that objective sleep markers could be part of a set of biomarkers that statistically forecast the longitudinal trajectory of cortical Aβ deposition in the human brain, and sleep may represent a potentially affordable, scalable, repeatable, and non-invasive tool for quantifying of Aβ pathological progression, prior to cognitive symptoms of Alzheimer's disease (AD).