Joshua D. Welch

TL;DR: In this paper, the authors show that the efficacy of immune-stimulatory gene therapy (TK/Flt3L) is enhanced in mIDH1 gliomas, due to the reprogramming of the myeloid cells' compartment infiltrating the tumor microenvironment (TME).

TL;DR: Welch et al. as mentioned in this paper derive a nonnegative matrix factorization algorithm for integrating single-cell datasets containing both shared and unshared features, incorporating an additional metagene matrix that allows un-shared features to inform the factorization.

TL;DR: SquiggleNet as mentioned in this paper is the first deep learning model that can classify nanopore reads directly from their electrical signals, and it operates faster than DNA passes through the pore, allowing realtime classification and read ejection.

TL;DR: It is demonstrated that microraft arrays, which are arrays containing thousands of individual cell culture sites, can be used to select single cells based on a variety of phenotypes, such as cell surface markers, cell proliferation and drug response, to select pancreatic cancer cells that proliferate in spite of cytotoxic drug treatment.

TL;DR: The sensitivity of EnD-Seq is increased by using cDNA priming to specifically enrich low-abundance tails of known sequence composition allowing identification of degradation intermediates, and the broad applicability of the computational approach is shown by using AppEnD to gain insight into 3' additions from diverse types of sequencing data, including data from small capped RNA sequencing and some alternative polyadenylation protocols.