Joshua D. Welch

TL;DR: Using high-throughput sequencing of histone mRNAs and degradation intermediates, it is found that knockdown of TUT7 reduces both the uridylation at the 3' end as well as uridolation of the major degradation intermediate in the stem.

TL;DR: Online integrative non-negative matrix factorization (iNMF) as discussed by the authors is an algorithm for integrating large, diverse and continually arriving single-cell datasets, which scales to arbitrarily large numbers of cells using fixed memory, iteratively incorporates new datasets as they are generated and allows many users to simultaneously analyze a single copy of a large dataset by streaming it over the internet.

TL;DR: This work developed a novel bioinformatic method for measuring pseudogene transcription from RNA-seq data and identified a set of 440 pseudogenes that are transcribed in breast cancer tissue, which increases the catalog of putative pseudogene ceRNAs and suggests that pseudogen transcription in cancer may play a larger role than previously appreciated.

TL;DR: These studies provide a detailed view of the word composition of several segments of the non-coding portion of the Arabidopsis genome, where each segment contains a unique word-based signature.

TL;DR: LIGER, an algorithm that delineates shared and dataset-specific features of cell identity, allowing flexible modeling of highly heterogeneous single-cell datasets, is developed and demonstrated its broad utility by applying it to four diverse and challenging analyses of human and mouse brain cells.