J
Jota Oyabu
Researcher at Osaka University
Publications - 15
Citations - 1969
Jota Oyabu is an academic researcher from Osaka University. The author has contributed to research in topics: Neointima & Drug-eluting stent. The author has an hindex of 10, co-authored 15 publications receiving 1722 citations.
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Journal ArticleDOI
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka,Shungo Hikoso,Osamu Yamaguchi,Manabu Taneike,Manabu Taneike,Toshihiro Takeda,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Hiroyuki Nakayama,Kazuhiko Nishida,Kazuhiko Nishida,Shizuo Akira,Akitsugu Yamamoto,Issei Komuro,Kinya Otsu,Kinya Otsu +16 more
TL;DR: It is shown that mitochondrial DNA that escapes from autophagy cell-autonomously leads to Toll-like receptor (TLR) 9-mediated inflammatory responses in cardiomyocytes and is capable of inducing myocarditis and dilated cardiopathy in DNase II-deficient mice.
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Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Manabu Taneike,Osamu Yamaguchi,Atsuko Nakai,Shungo Hikoso,Toshihiro Takeda,Isamu Mizote,Takafumi Oka,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Kazuhiko Nishida,Takahiko Shimizu,Masatsugu Hori,Issei Komuro,Takuji Shirasawa,Noboru Mizushima,Kinya Otsu +16 more
TL;DR: The results suggest that continuous constitutive autophagy has a crucial role in maintaining cardiac structure and function and the Atg5-deficient mice began to die after the age of 6 months.
Journal ArticleDOI
Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent: an angioscopic study.
Tomoaki Higo,Yasunori Ueda,Jota Oyabu,Katsuki Okada,Mayu Nishio,Akio Hirata,Kazunori Kashiwase,Nobuyuki Ogasawara,Shinichi Hirotani,Kazuhisa Kodama +9 more
TL;DR: The data suggest that the increased potential risk of late stent thrombosis in DES lesions may be due to the newly formed yellow neotima and cholesterol-laden plaque.
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Number of yellow plaques detected in a coronary artery is associated with future risk of acute coronary syndrome: detection of vulnerable patients by angioscopy.
Tomohito Ohtani,Yasunori Ueda,Isamu Mizote,Jota Oyabu,Katsuki Okada,Atsushi Hirayama,Kazuhisa Kodama +6 more
TL;DR: Patients with multiple yellow plaques per vessel have a higher risk of suffering ACS events than those with NYP 0 or 1, and angioscopy would be useful to detect vulnerable patients.
Journal ArticleDOI
Angioscopic evaluation of neointima coverage: sirolimus drug-eluting stent versus bare metal stent.
TL;DR: Sirolimus DESs, as compared with BMSs, were poorly covered by neointima and were accompanied by thrombus especially when there was a yellow plaque under the stents.