M
Manabu Taneike
Researcher at Osaka University
Publications - 32
Citations - 2376
Manabu Taneike is an academic researcher from Osaka University. The author has contributed to research in topics: Heart failure & Pressure overload. The author has an hindex of 15, co-authored 30 publications receiving 1911 citations. Previous affiliations of Manabu Taneike include King's College London.
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Journal ArticleDOI
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka,Shungo Hikoso,Osamu Yamaguchi,Manabu Taneike,Manabu Taneike,Toshihiro Takeda,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Hiroyuki Nakayama,Kazuhiko Nishida,Kazuhiko Nishida,Shizuo Akira,Akitsugu Yamamoto,Issei Komuro,Kinya Otsu,Kinya Otsu +16 more
TL;DR: It is shown that mitochondrial DNA that escapes from autophagy cell-autonomously leads to Toll-like receptor (TLR) 9-mediated inflammatory responses in cardiomyocytes and is capable of inducing myocarditis and dilated cardiopathy in DNase II-deficient mice.
Journal ArticleDOI
Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Manabu Taneike,Osamu Yamaguchi,Atsuko Nakai,Shungo Hikoso,Toshihiro Takeda,Isamu Mizote,Takafumi Oka,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Kazuhiko Nishida,Takahiko Shimizu,Masatsugu Hori,Issei Komuro,Takuji Shirasawa,Noboru Mizushima,Kinya Otsu +16 more
TL;DR: The results suggest that continuous constitutive autophagy has a crucial role in maintaining cardiac structure and function and the Atg5-deficient mice began to die after the age of 6 months.
Journal ArticleDOI
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Tomokazu Murakawa,Osamu Yamaguchi,Ayako Hashimoto,Shungo Hikoso,Toshihiro Takeda,Takafumi Oka,Hiroki Yasui,Hiromichi Ueda,Yasuhiro Akazawa,Hiroyuki Nakayama,Manabu Taneike,Tomofumi Misaka,Shigemiki Omiya,Ajay M. Shah,Akitsugu Yamamoto,Kazuhiko Nishida,Yoshinori Ohsumi,Koji Okamoto,Yasushi Sakata,Kinya Otsu +19 more
TL;DR: Bcl2-L-13 induces mitochondrial fragmentation in the absence of Drp1, while it induces mitophagy in Parkin-deficient cells and offers insights into mitochondrial quality control in mammalian cells.
Journal ArticleDOI
A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy.
TL;DR: It is shown that the ULK1 (unc-51-like kinase) complex is required for Bcl2-L-13 to processMitophagy, a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast.
Journal ArticleDOI
The IκB Kinase β/Nuclear Factor κB Signaling Pathway Protects the Heart From Hemodynamic Stress Mediated by the Regulation of Manganese Superoxide Dismutase Expression
Shungo Hikoso,Osamu Yamaguchi,Yuko Nakano,Toshihiro Takeda,Shigemiki Omiya,Isamu Mizote,Manabu Taneike,Takafumi Oka,Takahito Tamai,Jota Oyabu,Yoshihiro Uno,Yasushi Matsumura,Kazuhiko Nishida,Keiichiro Suzuki,Mikihiko Kogo,Masatsugu Hori,Kinya Otsu +16 more
TL;DR: The IKKβ/NF-&kgr;B signaling pathway plays a protective role in cardiomyocytes because of the attenuation of oxidative stress and JNK activation in a setting of acute pressure overload.