J
Joyce Suhy
Researcher at BioClinica
Publications - 59
Citations - 2199
Joyce Suhy is an academic researcher from BioClinica. The author has contributed to research in topics: Clinical trial & Medicine. The author has an hindex of 21, co-authored 52 publications receiving 1790 citations. Previous affiliations of Joyce Suhy include University of California, San Francisco & United States Department of Veterans Affairs.
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Journal ArticleDOI
Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
Paul S. Aisen,Serge Gauthier,Steven H. Ferris,Daniel Saumier,D. Haine,Denis Garceau,Anh Duong,Joyce Suhy,Joonmi Oh,Wan C. Lau,John S. Sampalis +10 more
TL;DR: Results must be interpreted in consideration of the limitations of clinical and disease-modification outcome measures and their relationship, the heterogeneity of the disease and the impact of confounding demographic and clinical variables.
Journal ArticleDOI
Standardization of analysis sets for reporting results from ADNI MRI data
Bradley T. Wyman,Danielle J Harvey,Karen Crawford,Matt A. Bernstein,Owen Carmichael,Patricia E. Cole,Paul K. Crane,Charles DeCarli,Nick C. Fox,Jeffrey L. Gunter,Derek L. G. Hill,Ronald J. Killiany,Chahin Pachai,Adam J. Schwarz,Norbert Schuff,Matthew L. Senjem,Joyce Suhy,Paul M. Thompson,Michael W. Weiner,Clifford R. Jack +19 more
TL;DR: Standard analysis sets of volumetric scans from ADNI‐1 have been created, comprising screening visits, 2‐year annual completers, and complete visits, and researchers are encouraged to test and report their techniques against these data.
Journal ArticleDOI
Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease
Clifford R. Jack,Frederik Barkhof,Matt A. Bernstein,Marc Cantillon,Patricia E. Cole,Charles DeCarli,Bruno Dubois,Simon Duchesne,Nick C. Fox,Giovanni B. Frisoni,Harald Hampel,Derek L. G. Hill,Keith A. Johnson,Jean Franc¸ois Mangin,Philip Scheltens,Adam J. Schwarz,Reisa A. Sperling,Joyce Suhy,Paul M. Thompson,Michael W. Weiner,Michael W. Weiner,Norman L. Foster +21 more
TL;DR: The European Alzheimer's Disease Centers-Alzheimer's Disease Neuroimaging Initiative hippocampal harmonization effort as a reference standard is described in this paper, and a publicly available reference standard data set based on manual delineation of the hippocampus in an appropriate sample of subjects is established.
Journal Article
Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease
Clifford R. Jack,Frederik Barkhof,Matt A. Bernstein,Marc Cantillon,Patricia E. Cole,Charles DeCarli,Bruno Dubois,Simon Duchesne,Nick C. Fox,Giovanni B. Frisoni,Harald Hampel,Derek L. G. Hill,Keith A. Johnson,Jean Franc¸ois Mangin,Philip Scheltens,Adam J. Schwarz,Reisa A. Sperling,Joyce Suhy,Paul M. Thompson,Michael W. Weiner,Michael W. Weiner,Norman L. Foster +21 more
TL;DR: Hippocampal volumetry is the most widely studied quantitative magnetic resonance imaging measure in Alzheimer's disease and thus represents the most rational target for an initial effort at standardization.
Journal ArticleDOI
Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease.
Stephen Salloway,Spyros Chalkias,Frederik Barkhof,Frederik Barkhof,Patrick Burkett,Jerome Barakos,Jerome Barakos,Derk D. Purcell,Derk D. Purcell,Joyce Suhy,Fiona Forrestal,Ying Tian,Kimberly Umans,Guanfang Wang,Priya Singhal,Samantha Budd Haeberlein,Karen Smirnakis +16 more
TL;DR: The EMERGE and ENGAGE phase 3 randomized clinical trials of aducanumab provided a robust data set to characterize amyloid-related imaging abnormalities (ARIA) that occur with treatment with treatment in patients with mild cognitive impairment due to Alzheimer disease or mild Alzheimer disease dementia as discussed by the authors.