J
Ju-Min Huang
Researcher at Macau University of Science and Technology
Publications - 19
Citations - 373
Ju-Min Huang is an academic researcher from Macau University of Science and Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 10 publications receiving 80 citations.
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Journal ArticleDOI
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Ju-Min Huang,Di Liu,Yuwei Wang,Liang Liu,Jian Li,Jing Yuan,Zhi-Hong Jiang,Ze-Bo Jiang,W.L. Wendy Hsiao,Haizhou Liu,Imran Khan,Ying Xie,Jian-Lin Wu,Ya-Jia Xie,Yi-Zhong Zhang,Yu Fu,Junyi Liao,Wen-Jun Wang,Huan-Ling Lai,A-Xi Shi,Jun Cai,Lian-Xiang Luo,Run-Ze Li,Xiao-Jun Yao,Xing-Xing Fan,Qibiao Wu,Zhongqiu Liu,Pei-Yu Yan,Jing-Guang Lu,Ming-Rong Yang,Lin Wang,Yabing Cao,Hong Wei,Elaine Lai-Han Leung +33 more
TL;DR: In this paper, the combination treatment of ginseng polysaccharides (GPs) and αPD-1 monoclonal antibody (mAb) could sensitise the response by modulating gut microbiota.
Journal ArticleDOI
Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer.
Ze-Bo Jiang,Wen-Jun Wang,Cong Xu,Ya-Jia Xie,Xuan-Run Wang,Yi-Zhong Zhang,Ju-Min Huang,Min Huang,Chun Xie,Pei Liu,Xing-Xing Fan,Yupo Ma,Pei-Yu Yan,Liang Liu,Xiao-Jun Yao,Qibiao Wu,Elaine Lai-Han Leung +16 more
TL;DR: In this paper, the effects and underlying mechanisms of luteolin, apigenin, and anti-PD-1 antibody combined with luteolins or apigenins on the PD-L1 expression and anti tumorigenesis in KRASmutant lung cancer were investigated.
Journal ArticleDOI
Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis.
Ze-Bo Jiang,Ju-Min Huang,Ya-Jia Xie,Yi Zhong Zhang,Chan Chang,Huan-Ling Lai,Wen-Jun Wang,Xiao-Jun Yao,Xing-Xing Fan,Qibiao Wu,Chun Xie,Meifang Wang,Elaine Lai-Han Leung,Elaine Lai-Han Leung +13 more
TL;DR: It is confirmed that evodiamine downregulates MUC1-C, resulting in modulating PD-L1 expression in non-small cell lung cancer (NSCLC), and indicates that evmodiamine represents a potential targeted agent suitable to be combined with immunotherapeutic approaches to treat NSCLC cancer patients.
Journal ArticleDOI
Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.
Ju-Min Huang,Ze-Bo Jiang,Yuwei Wang,Xiao-Qing Fan,Jun Cai,Xiao-Jun Yao,Liang Liu,Jun Huang,Jianxing He,Chun Xie,Qibiao Wu,Yabing Cao,Elaine Lai-Han Leung,Elaine Lai-Han Leung +13 more
TL;DR: The current research status of gut microbiota in immune checkpoint blockade therapies, clinical trials, underlying mechanisms and challenges of microbiome research in checkpoint immunotherapy are summarized to better disclose the interaction between gut microbiota and immune checkpoint inhibitors.
Journal ArticleDOI
Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling
Jia-Xin Li,Run-Ze Li,Ao Sun,Hua Zhou,Erwin Neher,Jia-Shun Yang,Ju-Min Huang,Yi-Zhong Zhang,Ze-Bo Jiang,Tu-Liang Liang,Lin-Rui Ma,Jian Wang,Xuan-Run Wang,Xiao-Qing Fan,Jie Huang,Ying Xie,Liang Liu,Ling Tang,Elaine Lai-Han Leung,Pei-Yu Yan +19 more
TL;DR: Wang et al. as mentioned in this paper investigated the pharmacological treatment mechanism of Weijing decoction in treating NSCLC via an integrated model of network pharmacology, metabolomics and biological methods.