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Xing-Xing Fan
Researcher at Macau University of Science and Technology
Publications - 68
Citations - 1235
Xing-Xing Fan is an academic researcher from Macau University of Science and Technology. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 15, co-authored 50 publications receiving 609 citations.
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Journal ArticleDOI
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Ju-Min Huang,Di Liu,Yuwei Wang,Liang Liu,Jian Li,Jing Yuan,Zhi-Hong Jiang,Ze-Bo Jiang,W.L. Wendy Hsiao,Haizhou Liu,Imran Khan,Ying Xie,Jian-Lin Wu,Ya-Jia Xie,Yi-Zhong Zhang,Yu Fu,Junyi Liao,Wen-Jun Wang,Huan-Ling Lai,A-Xi Shi,Jun Cai,Lian-Xiang Luo,Run-Ze Li,Xiao-Jun Yao,Xing-Xing Fan,Qibiao Wu,Zhongqiu Liu,Pei-Yu Yan,Jing-Guang Lu,Ming-Rong Yang,Lin Wang,Yabing Cao,Hong Wei,Elaine Lai-Han Leung +33 more
TL;DR: In this paper, the combination treatment of ginseng polysaccharides (GPs) and αPD-1 monoclonal antibody (mAb) could sensitise the response by modulating gut microbiota.
Journal ArticleDOI
Early lung cancer diagnostic biomarker discovery by machine learning methods.
Ying Xie,Wei-Yu Meng,Run-Ze Li,Yuwei Wang,Xin Qian,Chang Chan,Zhi-Fang Yu,Xing-Xing Fan,Hudan Pan,Chun Xie,Qibiao Wu,Pei-Yu Yan,Liang Liu,Yijun Tang,Xiao-Jun Yao,Meifang Wang,Elaine Lai-Han Leung,Elaine Lai-Han Leung +17 more
TL;DR: An interdisciplinary mechanism combines metabolomics and machine learning methods to improve lung cancer survival rate and the availability of blood-based screening could increase lung cancer patient uptake.
Journal ArticleDOI
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.
Xia Li,Xing-Xing Fan,Ze-Bo Jiang,Wings Ty Loo,Xiao-Jun Yao,Elaine Lai-Han Leung,Louis W.C. Chow,Liang Liu +7 more
TL;DR: Findings indicate that Shikonin can be an effective small molecule treating gefitinib‐resistant NSCLC and is closely associated with ROS elevation in the cells.
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Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer.
Ze-Bo Jiang,Wen-Jun Wang,Cong Xu,Ya-Jia Xie,Xuan-Run Wang,Yi-Zhong Zhang,Ju-Min Huang,Min Huang,Chun Xie,Pei Liu,Xing-Xing Fan,Yupo Ma,Pei-Yu Yan,Liang Liu,Xiao-Jun Yao,Qibiao Wu,Elaine Lai-Han Leung +16 more
TL;DR: In this paper, the effects and underlying mechanisms of luteolin, apigenin, and anti-PD-1 antibody combined with luteolins or apigenins on the PD-L1 expression and anti tumorigenesis in KRASmutant lung cancer were investigated.
Journal ArticleDOI
SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma.
Jun Huang,Xing-Xing Fan,Jiaxi He,Hui Pan,Run-Ze Li,Liyan Huang,Ze-Bo Jiang,Xiao-Jun Yao,Liang Liu,Elaine Lai-Han Leung,Jianxing He +10 more
TL;DR: Sterol-CoA desaturase-1 (SCD1) is identified which is the rate-limiting enzyme of unsaturated fatty acid synthesis, universally and highly expressed in lung adenocarcinoma and was required for the cell proliferation, migration and invasion.