J
Juan Fang
Researcher at Medical College of Wisconsin
Publications - 45
Citations - 1233
Juan Fang is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Medicine & Platelet. The author has an hindex of 15, co-authored 27 publications receiving 1052 citations. Previous affiliations of Juan Fang include Children's Hospital of Wisconsin.
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Journal ArticleDOI
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress.
Suelhem A. Mendoza,Juan Fang,David D. Gutterman,David A. Wilcox,Aaron H. Bubolz,Rongshan Li,Makoto Suzuki,David X. Zhang +7 more
TL;DR: Data indicate that TRPV4 may be a potential candidate of mechanosensitive channels in endothelial cells through which the shear stimulus is transduced into Ca(2+) signaling, leading to the release of endothelial relaxing factors and flow-mediated dilation of small resistance arteries.
Journal ArticleDOI
Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A.
Qizhen Shi,Qizhen Shi,Qizhen Shi,David A. Wilcox,David A. Wilcox,David A. Wilcox,Scot A. Fahs,Juan Fang,Juan Fang,Bryon D. Johnson,Bryon D. Johnson,Lily M. Du,Lily M. Du,Drashti Desai,Drashti Desai,Robert R. Montgomery,Robert R. Montgomery,Robert R. Montgomery +17 more
TL;DR: These results demonstrate that ectopic expression of FVIII in platelets by lentivirus‐mediated bone marrow transduction/transplantation may be a promising strategy for gene therapy of haemophilia A in humans.
Journal ArticleDOI
Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling
TL;DR: New insights are provided into the mechanism by which platelets become activated after exposure to heparin and hepar in-coated surfaces, and suggest that currently used glycoprotein IIb-IIIa inhibitors may be effective inhibitors of nonimmune forms of heparIn-induced platelet activation.
Journal ArticleDOI
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A
Lily M. Du,Paquita Nurden,Alan T. Nurden,Timothy C. Nichols,Dwight A. Bellinger,Eric S. Jensen,Eric S. Jensen,Sandra L. Haberichter,Sandra L. Haberichter,Elizabeth P. Merricks,Robin A. Raymer,Juan Fang,Juan Fang,Sevasti B. Koukouritaki,Sevasti B. Koukouritaki,Paula M. Jacobi,Troy Hawkins,Kenneth Cornetta,Qizhen Shi,David A. Wilcox +19 more
TL;DR: It is shown that haematopoietic stem cell gene therapy can prevent the occurrence of severe bleeding episodes in dogs with haemophilia A for at least 2.5 years after transplantation.
Journal ArticleDOI
Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia
Juan Fang,Kairbaan Hodivala-Dilke,Bryon D. Johnson,Lily M. Du,Richard O. Hynes,Gilbert C. White,David A. Wilcox +6 more
TL;DR: Bone marrow from β3-deficient (β3–/–) mice was transduced with the ITGβ3-cassette to investigate whether the platelet progeny could establish hemostasis in vivo, and human β3 formed a stable complex with murine αIIb, effectively restoring platelet function.