T
Troy Hawkins
Researcher at Indiana University
Publications - 32
Citations - 967
Troy Hawkins is an academic researcher from Indiana University. The author has contributed to research in topics: Protein function prediction & Hemolytic anemia. The author has an hindex of 16, co-authored 29 publications receiving 876 citations. Previous affiliations of Troy Hawkins include Eli Lilly and Company & Indiana University – Purdue University Indianapolis.
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Enhanced automated function prediction using distantly related sequences and contextual association by PFP
TL;DR: PFP is introduced, an automated function prediction server that provides the most probable annotations for a query sequence in each of the three branches of the Gene Ontology: biological process, molecular function, and cellular component.
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PFP: Automated prediction of gene ontology functional annotations with confidence scores using protein sequence data
TL;DR: A benchmark comparison shows significant performance improvement of PFP relative to GOtcha, InterProScan, and PSI‐BLAST predictions, consistent with the performance of P FP as the overall best predictor in both the AFP‐SIG ′05 and CASP7 function assessments.
Journal ArticleDOI
Function prediction of uncharacterized proteins.
Troy Hawkins,Daisuke Kihara +1 more
TL;DR: Several approaches beyond traditional sequence similarity that utilize the overwhelmingly large amounts of available data for computational function prediction, including structure-, association, interaction, interaction (cellular context)-, process, and proteomics-experiment-based methods are categorized.
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Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A
Lily M. Du,Paquita Nurden,Alan T. Nurden,Timothy C. Nichols,Dwight A. Bellinger,Eric S. Jensen,Eric S. Jensen,Sandra L. Haberichter,Sandra L. Haberichter,Elizabeth P. Merricks,Robin A. Raymer,Juan Fang,Juan Fang,Sevasti B. Koukouritaki,Sevasti B. Koukouritaki,Paula M. Jacobi,Troy Hawkins,Kenneth Cornetta,Qizhen Shi,David A. Wilcox +19 more
TL;DR: It is shown that haematopoietic stem cell gene therapy can prevent the occurrence of severe bleeding episodes in dogs with haemophilia A for at least 2.5 years after transplantation.
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ESG: extended similarity group method for automated protein function prediction
TL;DR: The extended similarity group (ESG) method, which performs iterative sequence database searches and annotates a query sequence with Gene Ontology terms, outperforms conventional PSI-BLAST and the protein function prediction (PFP) algorithm.