J
Julia A. Kaye
Researcher at University of California, San Francisco
Publications - 27
Citations - 2158
Julia A. Kaye is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 14, co-authored 21 publications receiving 1645 citations. Previous affiliations of Julia A. Kaye include Gladstone Institutes & University of California, Davis.
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Journal ArticleDOI
Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans.
Damien M. O'Halloran,Svetlana Altshuler-Keylin,Xiao-Dong Zhang,Chao He,Christopher Morales-Phan,Yawei Yu,Julia A. Kaye,Chantal Brueggemann,Tsung-Yu Chen,Tsung-Yu Chen,Noelle D. L'Etoile +10 more
TL;DR: It is demonstrated that CNG-3 is required in the AWC for adaptation to short (thirty minute) exposures of odor, and contains a candidate PKG phosphorylation site required to tune odor sensitivity.
Journal ArticleDOI
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.
Jonathan Z. Li,Ryan G. Lim,Julia A. Kaye,Victoria Dardov,Alyssa N. Coyne,Jie Wu,Pamela Milani,Andrew Cheng,Terri G. Thompson,Loren Ornelas,Aaron P. Frank,Miriam Adam,Maria G. Banuelos,Malcolm Casale,Veerle Cox,Renan Escalante-Chong,J. Gavin Daigle,Emilda Gomez,Lindsey R. Hayes,Ronald Holewenski,Susan Lei,Alexander LeNail,Leandro Lima,Berhan Mandefro,Andrea Matlock,Lindsay Panther,Natasha L. Patel-Murray,Jacqueline T. Pham,Divya Ramamoorthy,Karen Sachs,Brandon Shelley,Jennifer Stocksdale,Hannah Trost,Mark Wilhelm,Vidya Venkatraman,Brook T. Wassie,Stacia Wyman,Stephanie Y. Yang,Jennifer E. Van Eyk,Thomas E. Lloyd,Steven Finkbeiner,Ernest Fraenkel,Jeffrey D. Rothstein,Dhruv Sareen,Clive N. Svendsen,Leslie M. Thompson +45 more
TL;DR: In this article, the authors investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in C9ORF72.
Posted ContentDOI
The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein
Krystal A. Fontaine,Kristoffer E. Leon,Mir M. Khalid,David Jimenez-Morales,Julia A. Kaye,Priya S. Shah,Steven Finkbeiner,Nevan J. Krogan,Melanie Ott +8 more
TL;DR: It is proposed that ZIKV, via the capsid protein, has evolved a strategy to dampen antiviral activities of NMD, which subsequently contributes to neuropathology in vivo.
Journal ArticleDOI
Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries
Tomomi Imamura,Kyota Fujita,Kazuhiko Tagawa,Teikichi Ikura,Xigui Chen,Hidenori Homma,Takuya Tamura,Ying Mao,Juliana Bosso Taniguchi,Kazumi Motoki,Makoto Nakabayashi,Nobutoshi Ito,Kazunori D. Yamada,Kentaro Tomii,Hideyuki Okano,Julia A. Kaye,Steven Finkbeiner,Hitoshi Okazawa +17 more
TL;DR: Two oligopeptides, hepta-histidine (7H) and Angiotensin III, rescued the morphological abnormalities of primary neurons differentiated from iPS cells of human HD patients and proposed a possible common structure.
Journal ArticleDOI
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
Michael J. Workman,Ryan G. Lim,Jie Wu,Aaron T. Frank,Loren Ornelas,Lindsay Panther,Erick Galvez,Daniel Perez,Imara Meepe,Susan Lei,Viviana Valencia,Emilda Gomez,Chunyan Liu,Ruby Moran,L. Esparcia Pinedo.,Stanislav Tsitkov,Ritchie Ho,Julia A. Kaye,Terri G. Thompson,Jeffrey D. Rothstein,Steven Finkbeiner,Ernest Fraenkel,Dhruv Sareen,Leslie M. Thompson,Clive N. Svendsen +24 more
TL;DR: The Answer ALS data set as mentioned in this paper contains over 1,000 iPSC lines from control and amyotrophic lateral sclerosis (ALS) patients along with clinical and whole-genome sequencing data.