M
Maria G. Banuelos
Researcher at Cedars-Sinai Medical Center
Publications - 14
Citations - 558
Maria G. Banuelos is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 6, co-authored 11 publications receiving 370 citations. Previous affiliations of Maria G. Banuelos include Children's Hospital of Orange County & California State University.
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Journal ArticleDOI
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
Journal ArticleDOI
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Laperle Alexander,Samuel Sances,Yucer Nur,Victoria Dardov,Veronica J. Garcia,Ritchie Ho,A. N. Fulton,Matthew Jones,K. M. Roxas,Pablo Avalos,D. West,Maria G. Banuelos,Zhan Shu,Ramachandran Murali,N. T. Maidment,J. E. Van Eyk,M. Tagliati,Clive N. Svendsen +17 more
TL;DR: iPSC-derived midbrain dopaminergic neurons from patients with young-onset Parkinson’s disease exhibit molecular abnormalities, including elevated α-synuclein and lysosomal dysfunction, which can be normalized with phorbol ester treatment.
Journal ArticleDOI
Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae
Maria G. Banuelos,D. E. Moreno,Daniel K. Olson,Q. Nguyen,F. Ricarte,Christian R. Aguilera-Sandoval,Editte Gharakhanian +6 more
TL;DR: The results support linkage between severe hypersensitivity to hygromycin B and vacuolar defects and establish a new role in vacUolar and vesicular functions for two genes: PAF1, encoding a RNAP II-associated protein required for expression of cell cycle-regulated genes, and TPD3, encoding the regulatory subunit of protein phosphatase 2A.
Journal ArticleDOI
Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures.
Ritchie Ho,Michael J. Workman,Pranav Mathkar,Kathryn Wu,Kevin J. Kim,Jacqueline G. O’Rourke,Mariko Kellogg,Valerie Montel,Maria G. Banuelos,Olubankole Aladesuyi Arogundade,Sandra Diaz-Garcia,Daniel Oheb,Steven Huang,Irina Khrebtukova,Lisa Watson,John Ravits,Kevin Taylor,Robert H. Baloh,Clive N. Svendsen +18 more
TL;DR: In this article, a methodologies using single-cell RNA sequencing (scRNA-seq) analysis was presented to identify early, convergent, and MN-resolved signatures of ALS.
Journal ArticleDOI
Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial
Robert W. Baloh,J. Patrick Johnson,Pablo Avalos,Peggy Allred,Soshana P. Svendsen,Genevieve Gowing,K. M. Roxas,Amanda Wu,Becky Donahue,Sheryl Osborne,George M. Lawless,Brandon Shelley,Koral Wheeler,Carolyn Prina,Dana Fine,Tami Kendra-Romito,Haniah Stokes,Vicki Manoukian,Abirami Muthukumaran,Leslie Garcia,Maria G. Banuelos,Marlesa Godoy,Catherine Bresee,Hong-yan Yu,Doniel Drazin,Lindsey Ross,Robert T Naruse,Harish Babu,Eric A. Macklin,Ashley Vo,Ashraf Elsayegh,Warren G. Tourtellotte,M. Marcel Maya,Matthew Burford,Frank Diaz,Chirag G. Patil,Richard A. Lewis,Clive N. Svendsen +37 more
TL;DR: In this paper , human neural progenitor cells transduced with GDNF (CNS10-NPC-GDNF) differentiated to astrocytes protected spinal motor neurons and were safe in animal models.