J
Julia Feldmann
Researcher at Swiss Tropical and Public Health Institute
Publications - 24
Citations - 962
Julia Feldmann is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Mycobacterium tuberculosis complex & Mycobacterium tuberculosis. The author has an hindex of 12, co-authored 24 publications receiving 770 citations. Previous affiliations of Julia Feldmann include University of Basel.
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Journal ArticleDOI
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis
Guido V. Bloemberg,Peter M. Keller,David Stucki,Andrej Trauner,Sonia Borrell,Tsogyal D. Latshang,Mireia Coscolla,Thomas Rothe,Rico Hömke,Claudia Ritter,Julia Feldmann,Bettina Schulthess,Sebastien Gagneux,Erik C. Böttger +13 more
TL;DR: This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid, in multidrug-resistant Mycobacterium tuberculosis.
Journal ArticleDOI
Two New Rapid SNP-Typing Methods for Classifying Mycobacterium tuberculosis Complex into the Main Phylogenetic Lineages
David Stucki,David Stucki,Bijaya Malla,Bijaya Malla,Simon Hostettler,Simon Hostettler,Thembela Huna,Julia Feldmann,Julia Feldmann,Dorothy Yeboah-Manu,Sonia Borrell,Sonia Borrell,Lukas Fenner,Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Sebastien Gagneux,Sebastien Gagneux +17 more
TL;DR: Two complementary SNP-based genotyping methods to classify strains into the six main human-associated lineages of MTBC, the “Beijing” sublineage, and the clade comprising Mycobacterium bovis and Myc Cobacterium caprae are developed.
Journal ArticleDOI
Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis
Sonia Borrell,Youjin Teo,Federica Giardina,Federica Giardina,Elizabeth M. Streicher,Marisa Klopper,Julia Feldmann,Julia Feldmann,Borna Müller,Borna Müller,Borna Müller,Tommie C. Victor,Sebastien Gagneux,Sebastien Gagneux +13 more
TL;DR: The authors show that some mycobacteria carrying mutations conferring resistance to two antibiotics have a higher competitive fitness than corresponding strains carrying only one of these mutations.
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Nicolas Blondiaux,Martin Moune,Matthieu Desroses,Matthieu Desroses,Rosangela Frita,Marion Flipo,Vanessa Mathys,Karine Soetaert,Mehdi Kiass,Vincent Delorme,Vincent Delorme,Kamel Djaout,Vincent Trebosc,Christian Kemmer,René Wintjens,Alexandre Wohlkonig,Rudy Antoine,Ludovic Huot,David Hot,Mireia Coscolla,Mireia Coscolla,Julia Feldmann,Julia Feldmann,Sebastien Gagneux,Sebastien Gagneux,Camille Locht,Priscille Brodin,Marc Gitzinger,Benoit Deprez,Nicolas Willand,Alain R. Baulard +30 more
TL;DR: The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethion chloride-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide.
Journal ArticleDOI
Tracking a Tuberculosis Outbreak Over 21 Years: Strain-Specific Single-Nucleotide Polymorphism Typing Combined With Targeted Whole-Genome Sequencing
David Stucki,David Stucki,Marie Ballif,Thomas Bodmer,Mireia Coscolla,Mireia Coscolla,Anne-Marie Maurer,Sara Droz,Christa Butz,Sonia Borrell,Sonia Borrell,Christel Längle,Julia Feldmann,Julia Feldmann,Hansjakob Furrer,Carlo Mordasini,Peter Helbling,Hans L. Rieder,Hans L. Rieder,Matthias Egger,Sebastien Gagneux,Sebastien Gagneux,Lukas Fenner,Lukas Fenner +23 more
TL;DR: Strain-specific SNP genotyping allowed rapid and inexpensive identification of M. tuberculosis outbreak isolates in a population-based strain collection, and subsequent targeted WGS provided detailed insights into transmission dynamics.