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Iñaki Comas
Researcher at Spanish National Research Council
Publications - 163
Citations - 8482
Iñaki Comas is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Mycobacterium tuberculosis & Medicine. The author has an hindex of 36, co-authored 132 publications receiving 6765 citations. Previous affiliations of Iñaki Comas include Carlos III Health Institute & University of Pittsburgh.
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Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Tao Luo,Sonia Borrell,Sonia Borrell,Kathryn E. Holt,Midori Kato-Maeda,Julian Parkhill,Bijaya Malla,Bijaya Malla,Stefan Berg,Guy E. Thwaites,Dorothy Yeboah-Manu,Graham H. Bothamley,Jian Mei,Lan-Hai Wei,Stephen D. Bentley,Simon R. Harris,Stefan Niemann,Roland Diel,Abraham Aseffa,Qian Gao,Douglas B. Young,Douglas B. Young,Sebastien Gagneux,Sebastien Gagneux +26 more
TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
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Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
Iñaki Comas,Jaidip Chakravartti,Peter M. Small,James E. Galagan,Stefan Niemann,Kristin Kremer,Joel D. Ernst,Sebastien Gagneux,Sebastien Gagneux,Sebastien Gagneux +9 more
TL;DR: A genome-wide phylogeny based on genomes of 21 strains representative of the global diversity and six major lineages of the M. tuberculosis complex showed, as expected, that essential genes in MTBC were more evolutionarily conserved than nonessential genes.
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Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Kirsten I. Bos,Kelly M. Harkins,Alexander Herbig,Mireia Coscolla,Nico Weber,Iñaki Comas,Stephen Forrest,Josephine M. Bryant,Simon R. Harris,Verena J. Schuenemann,Tessa J. Campbell,Kerttu Majander,Alicia K. Wilbur,Ricardo Aníbal Guichón,Dawnie Wolfe Steadman,Della Collins Cook,Stefan Niemann,Marcel A. Behr,Martín José Zumárraga,Ricardo Bastida,Daniel H. Huson,Kay Nieselt,Douglas B. Young,Julian Parkhill,Jane E. Buikstra,Sebastien Gagneux,Anne C. Stone,Johannes Krause +27 more
TL;DR: Three 1,000-year-old mycobacterial genomes from Peruvian human skeletons are presented, revealing that a member of the M. tuberculosis complex caused human disease before contact and implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.
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Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.
Iñaki Comas,Sonia Borrell,Sonia Borrell,Andreas Roetzer,Graham Rose,Bijaya Malla,Bijaya Malla,Midori Kato-Maeda,James E. Galagan,James E. Galagan,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +12 more
TL;DR: These findings support a role for compensatory evolution in the global epidemics of MDR TB and show that M. tuberculosis strains harboring these compensatory mutations showed a high competitive fitness in vitro and were associated with high fitness in vivo.
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Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.
TL;DR: Strain lineages in MTBC should be defined based on phylogenetically robust markers such as single nucleotide polymorphisms or large sequence polymorphisms, and that for epidemiological purposes, MIRU-VNTR loci should be used in a lineage-dependent manner.