J
Julia Santiago
Researcher at University of Lausanne
Publications - 41
Citations - 5457
Julia Santiago is an academic researcher from University of Lausanne. The author has contributed to research in topics: Arabidopsis & Abscisic acid. The author has an hindex of 19, co-authored 33 publications receiving 4564 citations. Previous affiliations of Julia Santiago include Polytechnic University of Valencia & Max Planck Society.
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Journal ArticleDOI
Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins
Sang-Youl Park,Pauline Fung,Noriyuki Nishimura,Davin R. Jensen,Hiroaki Fujii,Yang Zhao,Shelley Lumba,Julia Santiago,Americo Rodrigues,Tsz-fung Freeman Chow,Simon E. Alfred,Dario Bonetta,Ruth R. Finkelstein,Nicholas J. Provart,Darrell Desveaux,Pedro L. Rodriguez,Peter McCourt,Jian-Kang Zhu,Julian I. Schroeder,Brian F. Volkman,Sean R. Cutler +20 more
TL;DR: PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs, illustrating the power of the chemical genetic approach for sidestepping genetic redundancy.
Journal ArticleDOI
Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
Julia Santiago,Americo Rodrigues,Angela Saez,Silvia Rubio,Regina Antoni,Florine Dupeux,Sang-Youl Park,José A. Márquez,Sean R. Cutler,Pedro L. Rodriguez +9 more
TL;DR: In this article, PYL5, PYL6 and PYL8 were identified as a cytosolic and nuclear ABA receptor that activates ABA signaling through direct inhibition of clade A PP2Cs.
Journal ArticleDOI
The abscisic acid receptor PYR1 in complex with abscisic acid
Julia Santiago,Florine Dupeux,Adam Round,Regina Antoni,Sang-Youl Park,Marc Jamin,Sean R. Cutler,Pedro L. Rodriguez,José A. Márquez +8 more
TL;DR: The crystal structure of Arabidopsis thaliana PYR1 is presented, which consists of a dimer in which one of the subunits is bound to ABA, indicating that conformational changes in these loops have a critical role in the stabilization of the hormone–receptor complex.
Journal ArticleDOI
Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
TL;DR: Crystal structures reveal why the brassinosteroid receptor kinase requires another kinase helper protein for activation and reveal how known missense mutations in BRI1 and in SERKs modulate brass inosteroid signaling and the targeting mechanism of B RI1 receptor antagonists.
Journal ArticleDOI
Triple loss of function of protein phosphatases type 2C leads to partial constitutive response to endogenous abscisic acid.
Silvia Rubio,Americo Rodrigues,Angela Saez,Marie B. Dizon,Alexander Gallé,Tae-Houn Kim,Julia Santiago,Jaume Flexas,Julian I. Schroeder,Pedro L. Rodriguez +9 more
TL;DR: Results indicate that ABA response is finely tuned by the integrated action of these genes, which is required to prevent a constitutive response to endogenous ABA that might have a deleterious effect on growth and development in the absence of environmental stress.