Davin R. Jensen

TL;DR: PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs, illustrating the power of the chemical genetic approach for sidestepping genetic redundancy.

TL;DR: In this paper, crystal structures of apo and ABA-bound receptors as well as a ternary PYL2-ABA-PP2C complex were reported, showing that apo receptors contain an open ligand-binding pocket flanked by a gate that closes in response to ABA by way of conformational changes in two highly conserved beta-loops.

TL;DR: It is shown that subtle differences between receptor binding pockets control ligand orientation between productive and nonproductive modes and this provides a robust framework for the design of new agonists and reveals a new mechanism for agonist selectivity.

TL;DR: Investigation of the effect of eight commercially available MS-compatible surfactants, two organic solvents, and two chaotropes on the enzymatic digestion efficiency of membrane protein-enriched complex mixtures in a multiphase study using a gelfree approach demonstrates that while Progenta anionic surfactant outperform other surfACTants when tested alone, combinations of guanidine and acetonitrile improve performance of all surfacts to near similar levels as well as enhance

TL;DR: Cyanabactin is a potent and selective agonist with a wide spectrum of ABA-like activities that defines subfamily IIIA receptors as key target sites for manipulating transpiration.