Valery Grinevich

TL;DR: In vivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats and demonstrates that OT release from local axonal endings can specifically control region-associated behaviors.

TL;DR: This work identifies a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.

TL;DR: It is observed that optogenetically induced oxytocin release enhanced olfactory exploration and same-sex recognition of adult rats and generates states for optimized information extraction in an early cortical top-down network that is required for social interactions with potential implications for sensory processing deficits in autism spectrum disorders.

TL;DR: The evolutionarily and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimbic social decision-making network, are discussed.

TL;DR: The present review draws attention to the non-synaptic axonal release in small and defined brain regions with the aim to clearly distinguish this way of oxytocin action from the classical synaptic transmission on one side and from dendritic release followed by a global diffusion on the other side.